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Researchers from University of Birmingham Detail Findings in Clinical Trials and Studies (Prospective Study of Serum 25-hydroxy Vitamin D and Tooth...

Clinical Trials Week


Researchers from University of Birmingham Detail Findings in Clinical Trials and Studies (Prospective Study of Serum 25-hydroxy Vitamin D and Tooth Loss)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Clinical Research. According to news reporting originating from Birmingham, United Kingdom, by NewsRx correspondents, research stated, "Vitamin D deficiency and oral diseases (periodontitis, caries, and tooth loss) are highly prevalent in Germany. Previous studies suggested that vitamin D might be a modifiable and protective factor for periodontitis, caries, and tooth loss."

Our news editors obtained a quote from the research from the University of Birmingham, "However, prospective studies investigating such associations are limited. We explored the association between the concentration of serum 25-hydroxy vitamin D (25OHD) and incidence of tooth loss, progression of clinical attachment loss (CAL) >= 3 mm, and progression of restorative and caries status in a population-based longitudinal study. We analyzed data from 1,904 participants from the Study of Health in Pomerania with a five-year follow-up. Generalized estimating equation models were applied to evaluate tooth-specific associations between serum 25OHD and incidence of tooth loss, progression of CAL >= 3 mm, and progression of restorative and caries status. Age, sex, education, smoking status, alcohol drinking, waist circumference, dental visit frequency, reasons of dental visit, vitamin D or calcium supplements, and season of blood draw were considered as confounders. Serum 25OHD was inversely associated with incidence of tooth loss. A significant dose-response relationship (p = .0022) was observed across the quintiles of serum 25OHD. After adjusting for multiple confounders, each 10-mu g/L increase of serum 25OHD was associated with a 13% decreased risk of tooth loss (risk ratio: 0.87; 95% confidence interval: 0.79, 0.96). The association was attenuated for changes of CAL >= 3 mm when adjusting for multiple confounders. No significant association was found between serum 25OHD and caries progression. Vitamin D might be a protective factor for tooth loss."

According to the news editors, the research concluded: "The effect might partially be mediated by its effect on periodontitis."

For more information on this research see: Prospective Study of Serum 25-hydroxy Vitamin D and Tooth Loss. Journal of Dental Research, 2014;93(7):639-644. Journal of Dental Research can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA. (Sage Publications -; Journal of Dental Research -

The news editors report that additional information may be obtained by contacting Y. Zhan, University of Birmingham, Sch Dental, Dept. of Oral Surg, Birmingham, W Midlands, United Kingdom. Additional authors for this research include S. Samietz, B. Holtfreter, A. Hannemann, P. Meisel, M. Nauck, H. Volzke, H. Wallaschofski, T. Dietrich and T. Kocher (see also Clinical Research).

Keywords for this news article include: Europe, Dentistry, Birmingham, Tooth Loss, Periodontitis, United Kingdom, Mouth Diseases, Tooth Diseases, Clinical Research, Periodontal Diseases, Stomatognathic Diseases, Clinical Trials and Studies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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