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Findings on Asthma Detailed by Investigators at University of Messina (25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the...

Respiratory Therapeutics Week


Findings on Asthma Detailed by Investigators at University of Messina (25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways)

By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- New research on Obstructive Lung Diseases is the subject of a report. According to news reporting originating in Messina, Italy, by NewsRx journalists, research stated, "Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease."

The news reporters obtained a quote from the research from the University of Messina, "We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR."

According to the news reporters, the research concluded: "Low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity."

For more information on this research see: 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways. Mediators of Inflammation, 2014;():1-10. Mediators of Inflammation can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing -; Mediators of Inflammation -

Our news correspondents report that additional information may be obtained by contacting A. Bonanno, University of Messina, Sch & Div Allergy & Clin Immunol, Dept. of Clin & Expt Med, Messina, Italy. Additional authors for this research include S. Gangemi, S. La Grutta, V. Malizia, L. Riccobono, P. Colombo, F. Cibella and M. Profita (see also Obstructive Lung Diseases).

Keywords for this news article include: Italy, Europe, Asthma, Messina, Pediatrics, Bronchial Diseases, Obstructive Lung Diseases, Respiratory Tract Diseases, Respiratory Hypersensitivity

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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