Research Conducted at University of Oklahoma Has Updated Our Knowledge about Obesity (Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular ...)
By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on Diet and Nutrition Disorders have been published. According to news reporting out of Oklahoma City, Oklahoma, by NewsRx editors, research stated, "Obesity in the elderly individuals is increasing at alarming rates and there is evidence suggesting that elderly individuals are more vulnerable to the deleterious cardiovascular effects of obesity than younger individuals. However, the specific mechanisms through which aging and obesity interact to promote the development of cardiovascular disease remain unclear."
Our news journalists obtained a quote from the research from the University of Oklahoma, "The present study was designed to test the hypothesis that aging exacerbates obesity-induced inflammation in perivascular adipose tissue, which contributes to increased vascular oxidative stress and inflammation in a paracrine manner. To test this hypothesis, we assessed changes in the secretome, reactive oxygen species production, and macrophage infiltration in periaortic adipose tissue of young (7 month old) and aged (24 month old) high-fat diet-fed obese C57BL/6 mice. High-fat diet-induced vascular reactive oxygen species generation significantly increased in aged mice, which was associated with exacerbation of endothelial dysfunction and vascular inflammation. In young animals, high-fat diet-induced obesity promoted oxidative stress in the perivascular adipose tissue, which was associated with a marked proinflammatory shift in the profile of secreted cytokines and chemokines. Aging exacerbated obesity-induced oxidative stress and inflammation and significantly increased macrophage infiltration in periaortic adipose tissue. Using cultured arteries isolated from young control mice, we found that inflammatory factors secreted from the perivascular fat tissue of obese aged mice promote significant prooxidative and proinflammatory phenotypic alterations in the vascular wall, mimicking the aging phenotype."
According to the news editors, the research concluded: "Overall, our findings support an important role for localized perivascular adipose tissue inflammation in exacerbation of vascular oxidative stress and inflammation in aging, an effect that likely enhances the risk for development of cardiovascular diseases from obesity in the elderly individuals."
For more information on this research see: Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences, 2013;68(7):780-92 (see also Diet and Nutrition Disorders).
Our news journalists report that additional information may be obtained by contacting L.C. Bailey-Downs, Reynolds Oklahoma Center on Aging, Dept. of Geriatric Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, United States. Additional authors for this research include Z. Tucsek, P. Toth, D. Sosnowska, T. Gautam, W.E. Sonntag, A. Csiszar and Z. Ungvari.
Keywords for this news article include: Obesity, Bariatrics, Cardiology, Immunology, Macrophages, Inflammation, Oklahoma City, United States, Overnutrition, Cardiovascular, North and Central America, Diet and Nutrition Disorders, Mononuclear Phagocyte System.
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