Uric acid may play crucial role in causing metabolic syndrome
Asian News International
The new research by
Brian J. DeBosch, MD, said the gut was an important clearance mechanism for uric acid, opening the door to new potential therapies for preventing or treating type 2 diabetes and metabolic syndrome.
Recent research by the paper's senior author,
The researchers also found that the drug allopurinol, which reduces uric acid production in the body and has long been used to treat gout, improved some, but not all, of the measures of metabolic health. Treatment with the drug lowered blood pressure and total cholesterol levels.
Exposure to uric acid would be impossible to avoid because it was a normal byproduct of cell turnover in the body. But there has been evidence that diet might contribute to uric acid levels. Many foods contain compounds called purines that break down into uric acid. And adding to growing concerns about fructose in the diet, evidence suggested that fructose metabolism in the liver also drives uric acid production.
The study is published in