New Obesity Findings from Rutgers State University Discussed (Artemisia extracts activate PPAR gamma, promote adipogenesis, and enhance insulin sensitivity in adipose tissue of obese Mice)
By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Diet and Nutrition Disorders. According to news reporting out of New Brunswick, New Jersey, by NewsRx editors, research stated, "Studies have shown that the inability of adipose tissue to properly expand during the obese state or respond to insulin can lead to metabolic dysfunction. Artemisia is a diverse group of plants that has a history of medicinal use."
Our news journalists obtained a quote from the research from Rutgers State University, "The aim of this study was to examine the ability of ethanolic extracts of Artemisia scoparia (SCO) and Artemisia santolinifolia (SAN) to modulate adipocyte development in cultured adipocytes and white adipose tissue (WAT) function in vivo using a mouse model of diet-induced obesity. Adipogenesis was assessed using Oil Red O staining and immunoblotting. A nuclear receptor specificity assay was used to examine the specificity of SCO- and SAN-induced PPAR gamma activation. C5713L/6J mice, fed a high-fat diet, were gavaged with saline, SCO, or SAN for 2 wk. Whole-body insulin sensitivity was examined using insulin tolerance tests. WAT depots were assessed via immunoblotting for markers of insulin action and adipokine production. We established that SCO and SAN were highly specific activators of PPAR gamma and did not activate other nuclear receptors. After a 1-wk daily gavage, SCO- and SAN-treated mice had lower insulin-induced glucose disposal rates than control mice. At the end of the 2-wk treatment period, SCO- and SAN-treated mice had enhanced insulin-responsive Akt serine-473 phosphorylation and significantly decreased monocyte chemotactic protein-1 levels in visceral WAT compared with control mice; these differences were depot specific. Moreover, plasma adiponectin levels were increased following SCO treatment."
According to the news editors, the research concluded: "Overall, these studies demonstrate that extracts from two Artemisia species can have metabolically favorable effects on adipocytes and WAT."
For more information on this research see: Artemisia extracts activate PPAR gamma, promote adipogenesis, and enhance insulin sensitivity in adipose tissue of obese Mice. Nutrition, 2014;30(7-8):S31-S36. Nutrition can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Nutrition - www.elsevier.com/wps/product/cws_home/525614)
Our news journalists report that additional information may be obtained by contacting A.J. Richard, Rutgers State University, Biotech Center, New Brunswick, NJ 08903, United States. Additional authors for this research include T.P. Burris, D. Sanchez-Infantes, Y.J. Wang, D.M. Ribnicky and J.M. Stephens (see also Diet and Nutrition Disorders).
Keywords for this news article include: Obesity, New Jersey, Bariatrics, PPAR gamma, Proinsulin, New Brunswick, United States, Peptide Hormones, DNA-Binding Proteins, Transcription Factors, North and Central America, Diet and Nutrition Disorders, Peroxisome Proliferator-Activated Receptors
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