Research Conducted at Guangxi Medical University Has Provided New Information about Diet and Nutrition (Systematic review and meta-analysis of the bone protective effect of phytoestrogens on osteoporosis in ovariectomized rats)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Health and Medicine. According to news reporting out of Guangxi, People's Republic of China, by NewsRx editors, research stated, "Phytoestrogens are candidate drugs for the treatment of osteoporosis. Many experiments have been designed to investigate the preventive effects of phytoestrogens for osteoporosis; however, it is easy for a single dissenting result from animal experiments to mislead clinical investigations."
Our news journalists obtained a quote from the research from Guangxi Medical University, "Herein, we use meta-analysis to assess the evidence for a protective effect of phytoestrogens on ovariectomized rat models of osteopenia. With respect to osteoporosis, PubMed and Web of Science were searched from January 2000 to March 2013 for relevant studies of phytoestrogens in ovariectomized rats. Two reviewers independently selected and assessed the studies. Data were aggregated using a random effects model. Meta-analysis revealed that the phytoestrogen treatment group demonstrated a significantly higher femur bone mineral density and trabecular bone and lower bone turnover markers (serum alkaline phosphatase and serum osteocalcin) compared with the control ovariectomized group, thus showing a bone protective effect of phytoestrogens in ovariectomized rats. Subsequent sensitivity analyses indicated that the effect of phytoestrogens on serum alkaline phosphatase and serum osteocalcin are not robust. Despite the high heterogeneity in the systematic review of animal experiments, the present results indicated that phytoestrogens may offer the most potential for the prevention of bone loss by reducing the expected loss of trabecular bone and bone mineral density. Their effects are likely due to inhibition of bone resorption, but their benefits on bone formation are still unclear."
According to the news editors, the research concluded: "Further studies are needed to assess the effect of phytoestrogens on bone formation and the efficacy and safety of individual phytoestrogens."
For more information on this research see: Systematic review and meta-analysis of the bone protective effect of phytoestrogens on osteoporosis in ovariectomized rats. Nutrition Research, 2014;34(6):467-477. Nutrition Research can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Nutrition Research - www.elsevier.com/wps/product/cws_home/525483)
Our news journalists report that additional information may be obtained by contacting S.W. Fu, Guangxi Med Univ, Affiliated Hosp 1, Dept. of Spine Osteopathia, Nanning 530021, Guangxi, People's Republic of China. Additional authors for this research include G.F. Zeng, S.H. Zong, Z.Y. Zhang, B. Zou, Y. Fang, L. Lu and D.Q. Xiao (see also Health and Medicine).
Keywords for this news article include: Asia, Guangxi, Health and Medicine, People's Republic of China
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