Study Findings on Colitis Are Outlined in Reports from Jiangxi University of Traditional Chinese Medicine (Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8CD11c cells)
By a News Reporter-Staff News Editor at Gastroenterology Week -- Data detailed on Digestive System Diseases and Conditions - Colitis have been presented. According to news reporting from Nanchang, People's Republic of China, by NewsRx journalists, research stated, "To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8CD11c cells. We evaluated the suppressive effect of Cur on CD8CD11c cells in spleen and Peyer's patches (PPs) in colitis induced by trinitrobenzene sulfonic acid."
The news correspondents obtained a quote from the research from the Jiangxi University of Traditional Chinese Medicine, "Mice with colitis were treated by 200 mg/kg Cur for 7 d. On day 8, the therapeutic effect of Cur was evaluated by visual assessment and histological examination, while co-stimulatory molecules of CD8CD11c cells in the spleen and PPs were measured by flow cytometry. The levels of interleukin (IL)-10, interferon (IFN)-g and transforming growth factor (TGF)-b1 in spleen and colonic mucosa were determined by ELISA. The disease activity index, colon weight, weight index of colon and histological score of experimental colitis were obviously decreased after Cur treatment, while the body weight and colon length recovered. After treatment with Cur, CD8CD11c cells were decreased in the spleen and PPs, and the expression of major histocompatibility complex II, CD205, CD40, CD40L and intercellular adhesion molecule-1 was inhibited. IL-10, IFN-g and TGF-b1 levels were increased compared with those in mice with untreated colitis."
According to the news reporters, the research concluded: "Cur can effectively treat experimental colitis, which is realized by inhibiting CD8CD11c cells."
For more information on this research see: Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8CD11c cells. World Journal of Gastroenterology, 2017;23(10):1804-1815. (Baishideng Publishing Group - www.wjgnet.com/; World Journal of Gastroenterology - www.wjgnet.com/1007-9327/current.htm)
Our news journalists report that additional information may be obtained by contacting H.M. Zhao, Hai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, People's Republic of China. Additional authors for this research include F. Han, R. Xu, X.Y. Huang, S.M. Cheng, M.F. Huang, H.Y. Yue, X. Wang, Y. Zou, H.L. Xu and D.Y Liu (see also Digestive System Diseases and Conditions - Colitis).
Keywords for this news article include: Asia, Spleen, Alkanes, Nanchang, Curcumin, Catechols, Hydrocarbons, Gastroenteritis, Diarylheptanoids, Gastroenterology, Organic Chemicals, Experimental Colitis, Hemic and Immune Systems, People's Republic of China, Colonic Diseases and Conditions, Digestive System Diseases and Conditions.
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