Data on Alzheimer Disease Reported by Researchers at Pablo de Olavide University (Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment)
By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been published. According to news reporting from Seville, Spain, by NewsRx journalists, research stated, "Tremendous progress has been made over the last few years in understanding how sleep and amyloid-beta (A beta) cooperate to speed up the progression of Alzheimer's disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathological cascade of AD."
The news correspondents obtained a quote from the research from Pablo de Olavide University, "Based on evidence showing that higher levels of homocysteine (HCY) and sleep loss increase oxidative damage, we here investigate whether the relationship between HCY and total antioxidant capacity (TAC) is mediated by changes in objective sleep in healthy older (HO, N = 21) and mild cognitive impairment (MCI, N = 21) subjects. Results revealed that reduced TAC levels in MCI was significantly correlated with increased HCY, shorter sleep duration, lower sleep efficiency, and reduced volume of temporal regions. However, only the HCY-TAC association showed diagnostic value, and this relationship was mediated by poorer sleep quality in MCI patients. We further showed that HCY-related cerebral volume loss in MCI depended on the serial relationship between poorer sleep quality and lower TAC levels."
According to the news reporters, the research concluded: "These findings provide novel insights into how impaired sleep may contribute to maintain the relationship between HCY and oxidative stress in prodromal AD, and offer empirical foundations to design therapeutic interventions aimed to weaken this link."
For more information on this research see: Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment. Scientific Reports, 2017;7():62-70. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)
Our news journalists report that additional information may be obtained by contacting J.L. Cantero, Pablo de Olavide Univ, Lab Funct Neurosci, Spanish Network Excellence Res Neurodegenerat Dis, Seville, Spain. Additional authors for this research include M. Atienza and M.P. Sanchez-Espinosa (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).
Keywords for this news article include: Seville, Spain, Europe, Neurodegenerative Diseases and Conditions, Homocysteine, Risk and Prevention, Sulfur Amino Acids, Alzheimer Disease, Pablo de Olavide University.
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