Recent Findings in Osteoporosis Described by Researchers from Huazhong University of Science and Technology (Conjugated linoleic acid prevents age-induced bone loss in mice by regulating both osteoblastogenesis and adipogenesis)
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Musculoskeletal Diseases and Conditions - Osteoporosis. According to news reporting originating in Hubei, People's Republic of China, by NewsRx journalists, research stated, "Osteoporosis (OP) can increase the risk of bone fracture and other complications, which is a major clinical problem. Previous researches have revealed that conjugated linoleic acid (CLA) can promote the bone formation."
Financial support for this research came from Administration of Traditional Chinese Medicine of Guangdong Province (see also Musculoskeletal Diseases and Conditions - Osteoporosis).
The news reporters obtained a quote from the research from the Huazhong University of Science and Technology, "But the mechanisms are not clear. Thus, we tested the hypothesis that CLA acts on bone formation might be via mTOR Complex1 (mTORC 1) pathway by in vitro and vivo assays. We studied the effect of CLA mix on MC3T3-E1 pre-osteoblasts differentiation into osteoblasts, and bone formation under osteoporotic conditions. At the same time, 3T3-L1 pre-adipocyte with the same CLA mix concentration gradient for 8 days with adipogenic differentiation medium. We found that Alkaline phosphatase (ALP), runt-related transcription factor 2 (RUNX2) and osteocalcin (OCN) expressions of pre-osteoblasts were up-regulated. Moreover in presence of CLA, peroxisome proliferators-activated receptor gamma(PPAR gamma) and CCAAT/enhancer-binding protein (C/EBP alpha) were down-regulated. Osteoporosis mice bone parameters in the distal femoral meraphysis were significantly increased compared with placebo mice. Furthermore, the phosphor-S6 (P-S6) was suppressed and phosphor-AKT (P-AKT) was up-regulated. Consistently, CLA can stimulate differentiation of osteoblasts and inhibited pre-adipocytes differentiated into adipocytes via AKT/mTORC1 signal pathway."
According to the news reporters, the research concluded: "Overall CLA thus be a suitable candidate for the treatment of patients with postmenopausal osteoporosis and obesity."
For more information on this research see: Conjugated linoleic acid prevents age-induced bone loss in mice by regulating both osteoblastogenesis and adipogenesis. Biochemical and Biophysical Research Communications, 2017;490(3):813-820. Biochemical and Biophysical Research Communications can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Biochemical and Biophysical Research Communications - www.journals.elsevier.com/biochemical-and-biophysical-research-communications/)
Our news correspondents report that additional information may be obtained by contacting H. Fang, Huazhong University of Science & Technology, Tongji Hosp, Tongji Med College, Dept. of Orthoped Surg, Wuhan, Hubei, People's Republic of China. Additional authors for this research include H. Wang, J. Dai, X. Li, M. Guan, S.T. Gao, Q. Ding, H.X. Wang and G.L. Lin.
Keywords for this news article include: Hubei, People's Republic of China, Asia, Musculoskeletal Diseases and Conditions, Metabolic Bone Diseases and Conditions, Bone Research, Osteoporosis, Genetics, Huazhong University of Science and Technology.
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