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Researchers at Inner Mongolia Autonomous Region People's Hospital Describe Findings in Vascular Dementia (Effect of glycosides of Cistanche on the...

Mental Health Weekly Digest

09-14-17

Researchers at Inner Mongolia Autonomous Region People's Hospital Describe Findings in Vascular Dementia (Effect of glycosides of Cistanche on the expression of mitochondrial precursor protein and keratin type II cytoskeletal 6A in a rat model ...)

By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Investigators publish new report on Cerebrovascular Diseases and Conditions - Vascular Dementia. According to news reporting out of Hohhot, People's Republic of China, by NewsRx editors, research stated, "Glycosides of (GC) is a preparation used extensively for its neuroprotective effect against neurological diseases, but its mechanisms of action remains incompletely understood. Here, we established a bilateral common carotid artery occlusion model of vascular dementia in rats and injected the model rats with a suspension of GC (10 mg/kg/day, intraperitoneally) for 14 consecutive days."

Our news journalists obtained a quote from the research from Inner Mongolia Autonomous Region People's Hospital, "Immunohistochemistry showed that GC significantly reduced p-tau and amyloid beta (Ab) immunoreactivity in the hippocampus of the model rats. Proteomic analysis demonstrated upregulation of mitochondrial precursor protein and downregulation of keratin type II cytoskeletal 6A after GC treatment compared with model rats that had received saline. Western blot assay confirmed these findings."

According to the news editors, the research concluded: "Our results suggest that the neuroprotective effect of GC in vascular dementia occurs the promotion of neuronal cytoskeleton regeneration."

For more information on this research see: Effect of glycosides of Cistanche on the expression of mitochondrial precursor protein and keratin type II cytoskeletal 6A in a rat model of vascular dementia. Neural Regeneration Research, 2017;12(7):1152-1158 (see also Cerebrovascular Diseases and Conditions - Vascular Dementia).

Our news journalists report that additional information may be obtained by contacting Y.M. Zhang, Dept. of Neurology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China. Additional authors for this research include W. Wu, W. Ma, F. Wang and J. Yuan.

Keywords for this news article include: Asia, Hohhot, Keratins, Scleroproteins, Vascular Dementia, People's Republic of China, Brain Diseases and Conditions, Cerebrovascular Diseases and Conditions, Neurodegenerative Diseases and Conditions, Central Nervous System Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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