Recent Findings from Department of Cardiology Provide New Insights into Type 2 Diabetes (Glycation of high-density lipoprotein triggers oxidative stress and promotes the proliferation and migration of vascular smooth muscle cells)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes. According to news reporting originating from Xiamen, People's Republic of China, by NewsRx correspondents, research stated, "In type 2 diabetes mellitus (T2DM), high-density lipoprotein (HDL) impairs its anti-atherogenic properties and even develops to a pro-inflammatory and pro-atherogenic phenotype because of abnormal compositions and modifications. In this study, we examined the effects and the related mechanisms of glycation of HDL on the proliferation and migration of vascular smooth muscle cells (VSMCs)."
Our news editors obtained a quote from the research from the Department of Cardiology, "Glycated HDL (G-HDL) was modified with D-glucose (25 mmol/L). Diabetic HDL (D-HDL) was isolated from T2DM patients. Rat VSMCs were isolated from the thoracic aortas. Human VSMCs were obtained from ScienCell Research Laboratories. Alpha-actin was detected through immunofluorescence. VSMC proliferation was assayed by Cell Count. VSMC migration was determined by transwell chamber and scratch-wound assay. Intracellular reactive oxygen species (ROS) was detected based on ROS-mediated 2',7'-dichlorofluorescein (DCFH-DA) fluorescence. Compared to native HDL (N-HDL), G-HDL remarkably promoted VSMC proliferation and migration in the dose and time-dependent manners. In addition, G-HDL enhanced ROS generation in VSMCs. However, the ROS scavenger, N-acetylcysteine, efficiently decreased ROS production and subsequently inhibited the proliferation of VSMCs induced by G-HDL. Similarly, D-HDL from T2DM patients also promoted ROS release and VSMC proliferation and migration. HDL either glycated or isolated from T2DM patients triggered VSMC proliferation, migration, and oxidative stress."
According to the news editors, the research concluded: "These results might partly interpret the higher morbidity of cardiovascular disease in T2DM patients."
For more information on this research see: Glycation of high-density lipoprotein triggers oxidative stress and promotes the proliferation and migration of vascular smooth muscle cells. Journal of Geriatric Cardiology, 2017;14(7):473-480 (see also Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes).
The news editors report that additional information may be obtained by contacting Q. Du, Dept. of Cardiology, the Affiliated Cardiovascular Hospital of Xiamen University, Medical College of Xiamen University, Xiamen, People's Republic of China. Additional authors for this research include M.M. Qian, P.L. Liu, L. Zhang, Y. Wang and D.H Liu.
Keywords for this news article include: Asia, Xiamen, Lipids, Lipoproteins, Muscle Cells, Type 2 Diabetes, Risk and Prevention, People's Republic of China, Non Insulin Dependent Diabetes Mellitus, Nutritional and Metabolic Diseases and Conditions.
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