Researchers' Work from Wayne State University Focuses on Diabetes (Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity)
By a News Reporter-Staff News Editor at Diabetes Week -- Investigators publish new report on Diabetes. According to news reporting out of Detroit, Michigan, by NewsRx editors, research stated, "Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent, its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus, gestational diabetes mellitus, and polycystic ovarian disease; more recently, experimental studies and observations in randomized clinical trials suggest that metformin could have a place in the treatment or prevention of preeclampsia."
Our news journalists obtained a quote from the research from Wayne State University, "This article provides a brief overview of the history of metformin in the treatment of diabetes mellitus and reviews the results of metaanalyses of metformin in gestational diabetes mellitus as well as the treatment of obese, non-diabetic, pregnant women to prevent macrosomia. We highlight the results of a randomized clinical trial in which metformin administration in early pregnancy did not reduce the frequency of large-for-gestational-age infants (the primary endpoint) but did decrease the frequency of preeclampsia (a secondary endpoint). The mechanisms by which metformin may prevent preeclampsia include a reduction in the production of antiangiogenic factors (soluble vascular endothelial growth factor receptor-1 and soluble endoglin) and the improvement of endothelial dysfunction, probably through an effect on the mitochondria. Another potential mechanism whereby metformin may play a role in the prevention of preeclampsia is its ability to modify cellular homeostasis and energy disposition, mediated by rapamycin, a mechanistic target. Metformin has a molecular weight of 129 Daltons and therefore readily crosses the placenta. There is considerable evidence to suggest that this agent is safe during pregnancy. New literature on the role of metformin as a chemotherapeutic adjuvant in the prevention of cancer and in prolonging life and protecting against aging is reviewed briefly."
According to the news editors, the research concluded: "Herein, we discuss the mechanisms of action and potential benefits of metformin."
For more information on this research see: Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. American Journal of Obstetrics and Gynecology, 2017;217(3):282-302. American Journal of Obstetrics and Gynecology can be contacted at: Mosby-Elsevier, 360 Park Avenue South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; American Journal of Obstetrics and Gynecology - www.journals.elsevier.com/american-journal-of-obstetrics-and-gynecology/)
Our news journalists report that additional information may be obtained by contacting R. Romero, Wayne State University, Center Mol Med & Genet, Detroit, MI 48202, United States. Additional authors for this research include O. Erez, M. Huttemann, M. Huttemann, B. Panaitescu, A. Conde-Agudelo, P. Pacora, B.H. Yoon and L.I. Grossman (see also Diabetes).
Keywords for this news article include: Detroit, Michigan, United States, North and Central America, Nutritional and Metabolic Diseases and Conditions, Endocrine System Diseases and Conditions, Platelet Aggregation Inhibitors, Glucose Metabolism Disorders, Pregnancy Complications, Cancer, Article Review, Coagulation Modifiers, Gestational Diabetes, Drugs and Therapies, Antiplatelet Agents, Hypoglycemic Agents, Antidiabetic Agents, Risk and Prevention, Metformin Therapy, Non-Sulfonylureas, Diabetes Mellitus, Aspirin Therapy, Pharmaceuticals, Women's Health, Endocrinology, Preeclampsia, Obstetrics, Biguanides, Oncology, Wayne State University.
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