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Researchers from Soochow University Report Details of New Studies and Findings in the Area of Neurovascular Research (Hyperfibrinogenemia is...

Obesity, Fitness & Wellness Week

09-15-17

Researchers from Soochow University Report Details of New Studies and Findings in the Area of Neurovascular Research (Hyperfibrinogenemia is Significantly Associated with an Increased Risk of In-hospital Mortality in Acute Ischemic Stroke ...)

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Vascular Research - Neurovascular Research is the subject of a report. According to news reporting originating from Suzhou, People's Republic of China, by NewsRx correspondents, research stated, "The impact of hyperfibrinogenemia on short-term outcomes after acute ischemic stroke (AIS) is still not well understood. We investigated the association between hyperfibrinogenemia upon hospital admission and the short-term prognosis of AIS patients."

Our news editors obtained a quote from the research from Soochow University, "A total of 3,212 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. Hyperfibrinogenemia was defined as having a serum fibrinogen > 4.0g/L. Cox proportional hazard and logistic regression models were used to estimate the effect of hyperfibrinogenemia on all-cause in-hospital mortality and poor discharge outcome (modified Rankin Scale score >= 3) in AIS patients. During hospitalization, 106 patients (3.3%) died from all-cause and 1226 (38.2%) patients experienced poor functional outcome at discharge. Multivariable model adjusted for age, sex, baseline National Institutes of Health Stroke Scale score, white blood cell count and other covariates, showed that hyperfibrinogenemia was associated with a 1.76-fold increase in the risk of in-hospital mortality (hazard ratio [HR] 1.76; 95% confidence interval [CI], 1.10-2.81; P-value=0.019). However, there was no significant association between hyperfibrinogenemia and poor outcome at discharge (adjusted odds ratios[OR] 1.15; 95% CI 0.86-1.53; P-value=0.338). Sensitivity and subgroup analyses also confirmed a significant association between hyperfibrinogenemia and in-hospital mortality."

According to the news editors, the research concluded: "In patients with AIS, hyperfibrinogenemia at the time of admission was independently associated with increased in-hospital mortality."

For more information on this research see: Hyperfibrinogenemia is Significantly Associated with an Increased Risk of In-hospital Mortality in Acute Ischemic Stroke Patients. Current Neurovascular Research, 2017;14(3):242-249. Current Neurovascular Research can be contacted at: Bentham Science Publ Ltd, Executive Ste Y-2, PO Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates. (Bentham Science Publishers - www.benthamscience.com; Current Neurovascular Research - www.benthamscience.com/cnr/index.htm)

The news editors report that additional information may be obtained by contacting Y.J. Cao, Soochow Univ, Inst Neurosci, Suzhou 215123, People's Republic of China. Additional authors for this research include X.W. Yin, H.H. Liu, D.N. Zheng, C.K. Zhong, H.P. Du, Y. Zhang, H.R. Zhao, C.H. Qiu, L.F. Fan, S.F. Pei, Z.X. Ma, S.J. You and C.F. Liu (see also Vascular Research - Neurovascular Research).

Keywords for this news article include: Suzhou, People's Republic of China, Asia, Neurovascular Research, Vascular Research, Hospital, Soochow University.

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