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Studies in the Area of Diet and Nutrition Reported from Menoufia University (Neuroprotective effects of food restriction on autonomic innervation of...

Health & Medicine Week

09-15-17

Studies in the Area of Diet and Nutrition Reported from Menoufia University (Neuroprotective effects of food restriction on autonomic innervation of the lacrimal gland in. the rat)

By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Diet and Nutrition is the subject of a report. According to news originating from Shibin Al Kawm, Egypt, by NewsRx correspondents, research stated, "Inflammatory mechanisms and oxidative stress play important roles in age-related lacrimal gland (LG) degeneration as well as neural degeneration. Research suggests that caloric restriction can prevent age related LG dysfunction and increase the life span of neurons."

Our news journalists obtained a quote from the research from Menoufia University, "In the present study, we hypothesized that caloric restriction prevents age-related LG dysfunction by ameliorating the influence of inflammatory/oxidative stress on autonomic neurons controlling lacrimal function. We evaluated the effects of food restriction (FR) on inflammatory/oxidative status and on autonomic neural/neuroglial cell populations in LGs from aging rats. A total of 45 female albino rats were divided into young adult, aged, and aged-FR groups. The FR group was subjected to a 50% reduction in food from 14 to 20 months of age. LG samples were collected for each group and subjected to biochemical, histological, and immunohistochemical studies. LGs from aged-FR rats, rather than those from aged rats, showed preservation of their cellular structures, organelles, and Schwan cell units. LG preservation was associated with a marked decrease in inflammatory markers, an increase in cellular antioxidants, and the up-regulation of choline acetyltransverase, tyrosine hydroxylase, neuron-specific enolase and S100."

According to the news editors, the research concluded: "These findings strongly suggest that in aged rats, both oxidative and inflammatory stressors directly contribute to LG dysfunction by mediating the degeneration of autonomic neurons, and that FR can protect against these effects."

For more information on this research see: Neuroprotective effects of food restriction on autonomic innervation of the lacrimal gland in. the rat. Annals of Anatomy-Anatomischer Anzeiger, 2017;213():8-18. Annals of Anatomy-Anatomischer Anzeiger can be contacted at: Elsevier Gmbh, Urban & Fischer Verlag, Office Jena, P O Box 100537, 07705 Jena, Germany (see also Diet and Nutrition).

The news correspondents report that additional information may be obtained from H.Z. Nooh, Menoufia Univ, Fac Med, Anat & Embryol Department, Shibin Al Kawm, Egypt. Additional authors for this research include G.H. El-Saify and N.M.N. Eldien.

Keywords for this news article include: Shibin Al Kawm, Egypt, Africa, Caloric Restriction, Diet and Nutrition, Menoufia University.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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