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New Findings from Tufts University Describe Advances in Insulin Resistance (Association between Serum Folate and Insulin Resistance among US...

Diabetes Week


New Findings from Tufts University Describe Advances in Insulin Resistance (Association between Serum Folate and Insulin Resistance among US Nondiabetic Adults)

By a News Reporter-Staff News Editor at Diabetes Week -- Investigators discuss new findings in Endocrine System Diseases and Conditions - Insulin Resistance. According to news reporting originating in Boston, Massachusetts, by NewsRx journalists, research stated, "Recent studies have suggested that epigenetic alterations, particularly DNA methylation, play a crucial role in the pathogenesis of insulin resistance. Folate is a key source of the one-carbon group for DNA methylation, whereas the association and mechanistic linkage between folate status and insulin resistance remains unclear with very limited experimental support."

The news reporters obtained a quote from the research from Tufts University, "We performed a cross-sectional study of 1530 nondiabetic adults in the 2011-2012 National Health and Nutrition Examination Survey (NHANES). We examined associations between serum folate and insulin resistance using multiple linear regression models adjusted for potential confounders. We detected a significant inverse relationship for serum folate, where a 25% increase in serum folate was associated with a 3.06% (95% CI, -4.72, -1.37) and 2.77% (95% CI, -4.36, -1.77) decline in HOMA-IR and insulin respectively, and a 2.55% (95% CI, 0.93, 4.21) increase in G/I ratio."

According to the news reporters, the research concluded: "Our findings demonstrate that serum folate was inversely associated with insulin resistance in U.S. nondiabetic adults."

For more information on this research see: Association between Serum Folate and Insulin Resistance among US Nondiabetic Adults. Scientific Reports, 2017;7():38-44. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Scientific Reports -

Our news correspondents report that additional information may be obtained by contacting Z.H. Liu, Tufts University, Jean Mayer Dept. of Agriculture Human Nutr Res Center Aging, Boston, MA 02111, United States. Additional authors for this research include C.E. Goh, R.T. Demmer, B.W. Whitcomb, P. Du and J.C. Li (see also Endocrine System Diseases and Conditions - Insulin Resistance).

Keywords for this news article include: Boston, Massachusetts, United States, North and Central America, Nutritional and Metabolic Diseases and Conditions, Endocrine System Diseases and Conditions, Glucose Metabolism Disorders, Insulin Resistance, Peptide Proteins, Peptide Hormones, Hyperinsulinism, Proinsulin, Genetics, Tufts University.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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