Recent Findings in Immunologic Receptors Described by Researchers from University of Jinan (Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin beta 3 Signaling)
By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Membrane Proteins - Immunologic Receptors. According to news reporting from Guangdong, People's Republic of China, by NewsRx journalists, research stated, "Targeting angiogenesis has emerged as a promising strategy for cancer treatment. Methylseleninic acid (MSA) is a metabolite of selenium (Se) in animal cells that exhibits anti-oxidative and anti-cancer activities at levels exceeding Se nutritional requirements."
The news correspondents obtained a quote from the research from the University of Jinan, "However, it remains unclear whether MSA exerts its effects on cancer prevention by influencing angiogenesis within Se nutritional levels. Herein, we demonstrate that MSA inhibited angiogenesis at 2 mu M, which falls in the range of moderate Se nutritional status. We found that MSA treatments at 2 mu M increased cell adherence, while inhibiting cell migration and tube formation of HUVECs in vitro. Moreover, MSA effectively inhibited the sprouts of mouse aortic rings and neoangiogenesis in chick embryo chorioallantoic membrane. We also found that MSA down-regulated integrin beta 3 at the levels of mRNA and protein, and disrupted clustering of integrin beta 3 on the cell surface."
According to the news reporters, the research concluded: "Additionally, results showed that MSA inhibited the phosphorylation of AKT, I kappa B alpha, and NF kappa B. Overall, our results suggest that exogenous MSA inhibited angiogenesis at nutritional Se levels not only by down-regulating the expression of integrin beta 3 but also by disorganizing the clustering of integrin beta 3, which further inhibited the phosphorylation involving AKT, I kappa B alpha, NF kappa B. These findings provide novel mechanistic insight into the function of MSA for regulating angiogenesis and suggest that MSA could be a potential candidate or adjuvant for anti-tumor therapy in clinical settings."
For more information on this research see: Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin beta 3 Signaling. Scientific Reports, 2017;7():451-463. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)
Our news journalists report that additional information may be obtained by contacting Z. Huang, Jinan Univ, Dept. of Biotechnol, Guangzhou, Guangdong, People's Republic of China. Additional authors for this research include L.B. Dong, C.W. Song, Y.Q. Zhang, C.H. Zhu, Y.B. Zhang, Q.J. Ling, P.R. Hoffmann, J. Li, Z.H. Cai and W. Li (see also Membrane Proteins - Immunologic Receptors).
Keywords for this news article include: Guangdong, People's Republic of China, Asia, Immunologic Receptors, Membrane Proteins, Chalcogens, Integrins, Selenium, Minerals, University of Jinan.
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