Researchers from Taipei Medical University Detail New Studies and Findings in the Area of Alzheimer Disease (The Association Between the Use of Zolpidem and the Risk of Alzheimer's Disease Among Older People)
By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Neurodegenerative Diseases and Conditions - Alzheimer Disease are discussed in a new report. According to news reporting originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "To evaluate the association between zolpidem use and the risk of Alzheimer's disease among older people. A retrospective cohort study using data from 2001 to 2011 from the National Health Insurance Research Database. Taiwan."
Funders for this research include National Science Council, Ministry of Science and Technology, Taiwan, Taipei Medical University (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).
Our news editors obtained a quote from the research from Taipei Medical University, "A total of 6,922 patients aged 65 years or older enrolled from January 2002 to December 2004 (the enrollment period). Zolpidem users were identified as patients who used zolpidem during the enrollment period. The index date was the date of the first zolpidem prescription. Dosage of zolpidem use was defined using cumulative defined daily dose (cDDD) based on the cumulative dosage that patients took within one year after the index date (grouped as: less than 28, 28-90, 91-180, and more than 180 cDDD). The occurrence of Alzheimer's disease was defined as the time period from the end of one year after the index date to the date of the Alzheimer's disease diagnosis. The propensity score was used to adjust the measured confounders of Alzheimer's disease. Cox proportional hazards models were used to evaluate the association between zolpidem use and the incidence of Alzheimer's disease. Zolpidem users with a high cumulative dose (>180 cDDD) in the first year after initiation had a significantly greater risk of Alzheimer's disease than non-zolpidem users (HR=2.97, 95% CI=1.61-5.49) and low cumulative dose (<28 cDDD) users (HR=4.18, 95% CI=1.77-9.86). We found the use of a high cumulative dose of zolpidem was associated with an increased risk of Alzheimer's disease among older people living in Taiwan."
According to the news editors, the research concluded: "It is advised to use caution when considering long-term use of zolpidem in older patients."
For more information on this research see: The Association Between the Use of Zolpidem and the Risk of Alzheimer's Disease Among Older People. Journal of the American Geriatrics Society, 2017;():. (Wiley-Blackwell - www.wiley.com/; Journal of the American Geriatrics Society - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1532-5415)
The news editors report that additional information may be obtained by contacting H.T. Cheng, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Additional authors for this research include F.J. Lin, S.R. Erickson, J.L. Hong and C.H Wu.
Keywords for this news article include: Taipei, Dementia, Tauopathies, Alzheimer Disease, Risk and Prevention, Brain Diseases and Conditions, Neurodegenerative Diseases and Conditions, Central Nervous System Diseases and Conditions.
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