Study Results from Institute of Chemistry Broaden Understanding of Science [(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats]
By a News Reporter-Staff News Editor at Science Letter -- A new study on Science is now available. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "Chronic cerebral hypoperfusion is a pathological state that is associated with the cognitive impairments in vascular dementia. Oxiracetam is a nootropic drug that is commonly used to treat cognitive deficits of cerebrovascular origins."
Our news journalists obtained a quote from the research from the Institute of Chemistry, "However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, we first identified that (S)-oxiracetam, but not ®-oxiracetam, was the effective ingredient that alleviated the impairments of spatial learning and memory by ameliorating neuron damage and white matter lesions, increasing the cerebral blood flow, and inhibiting astrocyte activation in chronic cerebral hypoperfused rats. Furthermore, using MALD-IMSI and LC-MS/MS, we demonstrated that (S)-oxiracetam regulated ATP metabolism, glutamine-glutamate and anti-oxidants in the cortex region of hypoperfused rats."
According to the news editors, the research concluded: "Altogether, our results strongly suggest that (S)-oxiracetam alone could be a nootropic drug for the treatment of cognitive impairments caused by cerebral hypoperfusion."
For more information on this research see: (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Scientific Reports, 2017;7():1607-1620. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)
Our news journalists report that additional information may be obtained by contacting Z.X. Nie, Chinese Academy Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, People's Republic of China. Additional authors for this research include H.H. Liu, H.J. Jiang, C. Wang, Y.F. Guo, Y. Sun, X. Zhao, X. Xiong, X.H. Zhang, K. Zhang, W. Li and X.P. Pu (see also Science).
Keywords for this news article include: Beijing, People's Republic of China, Asia, Science, Institute of Chemistry.
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