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Laboratory of Molecular Pathology Describes Findings in Amino Acids (The protein restriction mimetic Resveratrol is an autophagy inducer stronger...

Cancer Weekly

09-22-17

Laboratory of Molecular Pathology Describes Findings in Amino Acids (The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Amino Acids. According to news reporting from Novara, Italy, by NewsRx journalists, research stated, "The potential benefit of nutrient starvation in the prevention and treatment of cancer is presently under consideration. Resveratrol (RV), a dietary polyphenol acting as a protein (caloric) restriction mimetic, could substitute for amino acid starvation."

The news correspondents obtained a quote from the research from the Laboratory of Molecular Pathology, "The effects of starvation and of caloric restriction are mediated, among others, by autophagy, a process that contributes to cell homeostasis by promoting the lysosomal degradation of damaged and redundant self-constituents. Up-regulation of autophagy favors cell survival under nutrient shortage situation, and may drive cancer cells into a non-replicative, dormant state. Both RV and amino acid starvation effectively induced the aminoacid response and autophagy. These processes were associated with inhibition of the mTOR pathway and disruption of the BECLIN1-BCL-2 complex. The number of transcripts positively impinging on the autophagy pathway was higher in RV-treated than in starved cancer cells. Consistent with our data, it appears that RV treatment is more effective than and can substitute for starvation for inducing autophagy in cancer cells."

According to the news reporters, the research concluded: "The present findings are clinically relevant because of the potential therapeutic implications."

For more information on this research see: The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells. Molecular Carcinogenesis, 2017;():. (Wiley-Blackwell - www.wiley.com/; Molecular Carcinogenesis - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2744)

Our news journalists report that additional information may be obtained by contacting A. Ferraresi, Laboratory of Molecular Pathology, Dept. of Health Sciences, Universita del Piemonte Orientale A Avogadro, Novara, Italy. Additional authors for this research include R. Titone, C. Follo, A. Castiglioni, G. Chiorino, D.N. Dhanasekaran and C. Isidoro (see also Amino Acids).

Keywords for this news article include: Italy, Novara, Europe, Cancer, Oncology, Peptides, Proteins, Amino Acids, Diet and Nutrition, Caloric Restriction.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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