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Studies from Peking Union Medical College Yield New Information about Colitis (E-cadherin Mediates the Preventive Effect of Vitamin D-3 in...

Gastroenterology Week

09-22-17

Studies from Peking Union Medical College Yield New Information about Colitis (E-cadherin Mediates the Preventive Effect of Vitamin D-3 in Colitis-associated Carcinogenesis)

By a News Reporter-Staff News Editor at Gastroenterology Week -- Data detailed on Digestive System Diseases and Conditions - Colitis have been presented. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Vitamin D-3 is beneficial in ameliorating or preventing inflammation and carcinogenesis. Here, we evaluated if vitamin D-3 has a preventive effect on colitis-associated carcinogenesis."

The news correspondents obtained a quote from the research from Peking Union Medical College, "Administration of azoxymethane (AOM), followed with dextran sulfate sodium (DSS), was used to simulate colitis-associated colon cancer in mice. The supplement of vitamin D-3 at different dosages (15, 30, 60 IU.g(-1).w(-1)), started before AOM or immediately after DSS treatment (post 60), was sustained to the end of the experiment. Dietary vitamin D-3 significantly reduced the number of tumors and tumor burden in a dose-dependent manner. Of note, vitamin D-3 in high doses showed significant preventive effects on carcinogenesis regardless of administration before or after AOM-DSS treatment. Cell proliferation decreased in vitamin D-3 groups compared with the control group after inhibition of expression of beta-catenin and its downstream target gene cyclin D1 in the colon. In vitro, vitamin D-3 reduced the transcriptional activity and nuclear level of beta-catenin, and it also increased E-cadherin expression and its binding affinity for beta-catenin. Moreover, repression of E-cadherin was rescued by supplemental vitamin D-3 in mouse colons. Taken together, our results indicate that vitamin D-3 effectively suppressed colonic carcinogenesis in the AOM-DSS mouse model."

According to the news reporters, the research concluded: "Our findings further suggest that upregulation of E-cadherin contributes to the preventive effect of vitamin D-3 on beta-catenin activity."

For more information on this research see: E-cadherin Mediates the Preventive Effect of Vitamin D-3 in Colitis-associated Carcinogenesis. Inflammatory Bowel Diseases, 2017;23(9):1535-1543. Inflammatory Bowel Diseases can be contacted at: Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Wiley-Blackwell - www.wiley.com/; Inflammatory Bowel Diseases - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1536-4844)

Our news journalists report that additional information may be obtained by contacting H.Y. Wang, Peking Union Med College, Beijing 100021, People's Republic of China. Additional authors for this research include L.M. He, Z.J. Luan, H. Lv, H. Yang, Y. Zhou, X.H. Zhao, W.X. Zhou, S.L. Yu, B. Tan, Y. Xin and J.M. Qian (see also Digestive System Diseases and Conditions - Colitis).

Keywords for this news article include: Beijing, People's Republic of China, Asia, Digestive System Diseases and Conditions, Gastrointestinal Diseases and Conditions, Colonic Diseases and Conditions, Armadillo Domain Proteins, Cell Adhesion Molecules, Transcription Factors, Membrane Proteins, Gastroenterology, Gastroenteritis, Carcinogenesis, Cell Research, Glycoproteins, beta Catenin, Cadherins, Catenins, Colitis, Peking Union Medical College.

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