New Findings from Ningbo University Yields New Data on Alzheimer Disease (Fucoxanthin, a Marine Carotenoid, Attenuates b-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells)
By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on Neurodegenerative Diseases and Conditions - Alzheimer Disease is the subject of a report. According to news reporting from Ningbo, People's Republic of China, by NewsRx journalists, research stated, "Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of -amyloid (A) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD."
Funders for this research include K. C. Wong Magna Fund in Ningbo University, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund, Scientific Research Foundation for the Returned Overseas Chinese Scholars, National 111 Project of China, Ningbo Municipal Innovation Team of Life Science and Health, Ningbo International Science and Technology Cooperation Project, National Natural Science Foundation of China, Applied Research Project on Nonprofit Technology of Zhejiang Province, Natural Science Foundation of Zhejiang Province (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).
The news correspondents obtained a quote from the research from Ningbo University, "In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented A oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells. A oligomers inhibited the prosurvival phosphoinositide 3-kinase (PI3K)/Akt cascade and activated the proapoptotic extracellular signal-regulated kinase (ERK) pathway. Moreover, inhibitors of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase (MEK) synergistically prevented A oligomer-induced neuronal death, suggesting that the PI3K/Akt and ERK pathways might be involved in A oligomer-induced neurotoxicity. Pretreatment with fucoxanthin significantly prevented A oligomer-induced alteration of the PI3K/Akt and ERK pathways. Furthermore, LY294002 and wortmannin, two PI3K inhibitors, abolished the neuroprotective effects of fucoxanthin against A oligomer-induced neurotoxicity."
According to the news reporters, the research concluded: "These results suggested that fucoxanthin might prevent A oligomer-induced neuronal loss and oxidative stress via the activation of the PI3K/Akt cascade as well as inhibition of the ERK pathway, indicating that further studies of fucoxanthin and related compounds might lead to a useful treatment of AD."
For more information on this research see: Fucoxanthin, a Marine Carotenoid, Attenuates b-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity, 2017;2017():6792543. (Hindawi Publishing - www.hindawi.com; Oxidative Medicine and Cellular Longevity - www.hindawi.com/journals/oximed/)
Our news journalists report that additional information may be obtained by contacting J. Lin, Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, People's Republic of China. Additional authors for this research include J. Yu, J. Zhao, K. Zhang, J. Zheng, J. Wang, C. Huang, J. Zhang, X. Yan, W.H. Gerwick, Q. Wang, W. Cui and S. He.
Keywords for this news article include: Asia, Cells, Ningbo, Kinase, Amyloid, Neurons, Polyenes, Proteins, Terpenes, Carotenoids, Cyclohexenes, Hydrocarbons, Cycloparaffins, Alzheimer Disease, Organic Chemicals, Biological Factors, Biological Pigments, Enzymes and Coenzymes, People's Republic of China, Neurodegenerative Diseases and Conditions.
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