Studies from Bharathidasan University Update Current Data on Alzheimer Disease (Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AbPP in Familial Alzheimer's Disease)
By a News Reporter-Staff News Editor at Drug Week -- Research findings on Neurodegenerative Diseases and Conditions - Alzheimer Disease are discussed in a new report. According to news reporting out of Tiruchirappalli, India, by NewsRx editors, research stated, "Deterioration of cholesterol metabolism has recently been a frontier subject of investigation in the field of Alzheimer's disease (AD). Though amyloid-b protein precursor (AbPP) primes the pathological cascade, changes in cholesterol levels and its intermediates, geranyl geranyl pyrophosphate and farnesyl pyrophosphate, is expected to have a different consequence on AbPP processing and amyloid-b (Ab) generation."
Our news journalists obtained a quote from the research from Bharathidasan University, "However, the use of statins (HMG-COA reductase inhibitor) has been widely implicated in slowing down the pathogenic progression of AD, while the epidemiological reports on its biological effect remains controversial. Considering this fact, the choice of drug that could maintain cholesterol homeostasis without altering its biosynthesis may yield a better therapeutic efficacy on AD. Thus, the present study focused on determining the influence of cholesterol and isoprenoids on amyloidogenic-cleavage of AbPP, in addition to resveratrol as a potent therapeutic drug in CHO-APPswe cell lines. High levels of cholesterol were found to enhance the maturation of AbPP and altered the expression and subcellular localization of ADAM10, BACE1, and PS1 thereby promoting Ab generation, whereas high isoprenoids increased both maturation as well as amyloidogenic-cleavage of AbPP, which was evident through b-CTF production."
According to the news editors, the research concluded: "Interestingly, the therapeutic efficacy of resveratrol maintained cholesterol homeostasis and reduced the amyloidogenic burden through its ability to enhance SIRT1 expression and thereby regulating differential expression of AD determinants."
For more information on this research see: Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AbPP in Familial Alzheimer's Disease. Journal of Alzheimer's Disease, 2017;60(s1):S3-S23. Journal of Alzheimer's Disease can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).
Our news journalists report that additional information may be obtained by contacting M. Sathya, Molecular Gerontology Laboratory, Dept. of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu, India. Additional authors for this research include P. Moorthi, P. Premkumar, M. Kandasamy, K.S. Jayachandran and M. Anusuyadevi.
Publisher contact information for the Journal of Alzheimer's Disease is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.
Keywords for this news article include: Asia, India, Therapy, Dementia, Cholesterol, Tauopathies, Epidemiology, Tiruchirappalli, Alzheimer Disease, Brain Diseases and Conditions, Neurodegenerative Diseases and Conditions, Central Nervous System Diseases and Conditions.
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