Study Results from Central University of Punjab Provide New Insights into Alzheimer Disease (Phytochemical Ginkgolide B Attenuates Amyloid-b1-42 Induced Oxidative Damage and Altered Cellular Responses in Human Neuroblastoma SH-SY5Y Cells)
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been presented. According to news reporting from Punjab, India, by NewsRx journalists, research stated, "Oxidative stress is an upsurge in reactive oxygen/nitrogen species (ROS/RNS), which aggravates damage to cellular components viz. lipids, proteins, and nucleic acids resulting in impaired cellular functions and neurological pathologies including Alzheimer's disease (AD). In the present study, we have examined amyloid-b (Ab)-induced oxidative stress responses, a major cause for AD, in the undifferentiated and differentiated human neuroblastoma SH-SY5Y cells."
The news correspondents obtained a quote from the research from the Central University of Punjab, "Ab1-42-induced oxidative damage was evaluated on lipids by lipid peroxidation; proteins by protein carbonyls; antioxidant status by SOD and GSH enzyme activities; and DNA and RNA damage levels by evaluating the number of AP sites and 8-OHG base damages produced. In addition, the neuro-protective role of the phytochemical ginkgolide B (GB) in countering Ab1-42-induced oxidative stress was assessed. We report that the differentiated cells are highly vulnerable to Ab1-42-induced oxidative stress events as exerted by the deposition of Ab in AD. Results of the current study suggest that the pre-treatment of GB, followed by Ab1-42 treatment for 24 h, displayed neuro-protective potential, which countered Ab1-42-induced oxidative stress responses in both undifferentiated and differentiated SH-SY5Y neuronal cells by: 1) hampering production of ROS and RNS; 2) reducing lipid peroxidation; 3) decreasing protein carbonyl content; 4) restoring antioxidant activities of SOD and GSH enzymes; and 5) maintaining genome integrity by reducing the oxidative DNA and RNA base damages."
According to the news reporters, the research concluded: "Ab1-42 induces oxidative damage to the cellular biomolecules, which are associated with AD pathology, and are protected by the pre-treatment of GB against Ab-toxicity. Taken together, this study advocates for phytochemical-based therapeutic interventions against AD."
For more information on this research see: Phytochemical Ginkgolide B Attenuates Amyloid-b1-42 Induced Oxidative Damage and Altered Cellular Responses in Human Neuroblastoma SH-SY5Y Cells. Journal of Alzheimer's Disease, 2017;60(s1):S25-S40. Journal of Alzheimer's Disease can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).
Our news journalists report that additional information may be obtained by contacting I. Gill, Centre for Animal Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India. Additional authors for this research include S. Kaur, N. Kaur, M. Dhiman and A.K Mantha.
Publisher contact information for the Journal of Alzheimer's Disease is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.
Keywords for this news article include: Asia, India, Punjab, Amyloid, Genetics, Oncology, Proteins, Diterpenes, Hematology, Ginkgolides, Neuroblastomas, Alzheimer Disease, Neurodegenerative Diseases and Conditions.
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