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New Celecoxib Therapy Study Results from Sichuan Agricultural University Described (2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a...

Drug Week

09-29-17

New Celecoxib Therapy Study Results from Sichuan Agricultural University Described (2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling)

By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Drugs and Therapies - Celecoxib Therapy are presented in a new report. According to news reporting out of Chengdu, People's Republic of China, by NewsRx editors, research stated, "The search for antiaging drugs is a key component of gerontology research. A few drugs with positive effects on life span in model organisms have been found."

Financial support for this research came from National Natural Science Foundation of China (see also Drugs and Therapies - Celecoxib Therapy).

Our news journalists obtained a quote from the research from Sichuan Agricultural University, "Here, we report that 2,5-dimethyl-celecoxib, a derivative of the anti-inflammatory drug celecoxib, can extend Drosophila life span and delay aging by a mechanism involving insulin signaling and target of rapamycin signaling. Importantly, its positive effects were apparent when the treatment window was restricted to the beginning of life or the later half. 2,5-Dimethyl-celecoxib-induced longevity was also associated with improvements in physical activity, intestinal integrity, and increased autophagy. In addition, 2,5-dimethyl-celecoxib exhibited protective effects against several kinds of stress such as starvation and heat."

According to the news editors, the research concluded: "The generally positive effects of 2,5-dimethyl-celecoxib on both health and life span, combined with its mode of action via evolutionarily conserved signaling pathways, indicate that it has the potential to become an effective antiaging drug."

For more information on this research see: 2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences, 2017;72(10):1334-1341.

Our news journalists report that additional information may be obtained by contacting Q. Wu, Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, People's Republic of China. Additional authors for this research include T. Lian, X. Fan, C. Song, U. Gaur, X. Mao, D. Yang, M.DW. Piper and M. Yang.

Keywords for this news article include: Asia, Pharmaceuticals, Chengdu, Analgesics, Proinsulin, COX 2 Inhibitors, Peptide Hormones, Peptide Proteins, Celecoxib Therapy, Drugs and Therapies, People's Republic of China, Central Nervous System Agents.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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