Findings from University of Pittsburgh Broaden Understanding of Geriatrics and Gerontology (Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Aging Research - Geriatrics and Gerontology are discussed in a new report. According to news reporting originating in Pittsburgh, Pennsylvania, by NewsRx journalists, research stated, "Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity. Using data from the Long Life Family Study, we performed genomewide association analyses on an endophenotype construct, LF1, comprising a linear combination of traits across health domains."
The news reporters obtained a quote from the research from the University of Pittsburgh, "LF1 primarily reflected traits from the pulmonary and physical activity domains. We detected a significant association between LF1 and a locus on chromosome 10p15 (p-value = 4.65 x 10(-8)) and suggestive evidence (p-value < 5 x 10(-6)) for association on chromosomes 1, 2, 8, 12, 15, 18, and 22. Using data from the Health, Aging and Body Composition Study, we subsequently replicated the association for the 1p13 region near the NBPF6 locus (p-value = 3.65 x 10(-4)). Our analyses indicate that loci influencing a healthy aging endophenotype construct predominantly comprised of pulmonary and physical function domains may be located on chromosome 1p13 near the NBPF6 locus."
According to the news reporters, the research concluded: "Further investigation of this possible locus and other suggestive loci may reveal novel biological pathways that influence healthy aging."
For more information on this research see: Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2017;72(10):1411-1416. Journals of Gerontology Series A-Biological Sciences and Medical Sciences can be contacted at: Oxford Univ Press Inc, Journals Dept, 2001 Evans Rd, Cary, NC 27513, USA (see also Aging Research - Geriatrics and Gerontology).
Our news correspondents report that additional information may be obtained by contacting J. Singh, University of Pittsburgh, Dept. of Human Genet, Pittsburgh, PA 15260, United States. Additional authors for this research include R.L. Minster, N. Schupf, A. Kraja, Y.M. Liu, K. Christensen, A.B. Newman and C.M. Kammerer.
Keywords for this news article include: Pittsburgh, Pennsylvania, United States, North and Central America, Geriatrics and Gerontology, Aging Research, University of Pittsburgh.
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