Studies from Department of Neonatology Update Current Data on Vitamin D Deficiency (Multi-dose vitamin d supplementation in stable very preterm infants: Prospective randomized trial response to three different vitamin D supplementation doses)
By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency. According to news reporting from Ankara, Turkey, by NewsRx journalists, research stated, "Preterm newborns are born with lower vitamin D stores. Although vitamin D supplementation is recommended there is no consensus regarding the adequate dose of supplementation for preterm infants."
The news correspondents obtained a quote from the research from the Department of Neonatology, "To assess the effect of three different doses of vitamin D supplementation (400, 800 and 1000 IU/d) in preterm infants 5 32 weeks gestation on the prevalence of vitamin D deficiency and 25(OH) D levels at 36 weeks postmenstrual age (PMA). Prospective randomized trial. 121 preterm infants with gestational age of 24-32 weeks were randomly allocated to receive 400, 800 or 1000 IU/d vitamin D. Serum concentration of 25(OH)D and the prevalence of vitamin D deficiency at 36 weeks PMA. Vitamin D deficiency was defined as serum 25(OH)D concentrations < 20 ng/ml. Of the 121 infants 72% had deficient vitamin D levels before supplementation. The average 25(OH) vitamin D concentrations at 36 weeks PMA were significantly higher in 800 IU (40 +/- 21.4 ng/ml) and 1000 IU group (43 +/- 18.9 ng/ml) when compared to 400 IU group (29.4 +/- 13 ng/ml). The prevalence of vitamin D deficiency (2.5 vs 22.5; RR: 0.09; CI:0.01-0.74) and insufficiency (30 vs 57.5; RR:0.32; CI:0.13-0.80) was significantly lower in 1000 IU group when compared to 400 IU group at 36 weeks PMA."
According to the news reporters, the research concluded: "1000 IU/d of vitamin D supplementation in preterm infants 5 32 weeks gestation age effectively decreases the prevalence of vitamin D deficiency and leads to higher concentrations of 25(OH) vitamin D at 36 weeks PMA."
For more information on this research see: Multi-dose vitamin d supplementation in stable very preterm infants: Prospective randomized trial response to three different vitamin D supplementation doses. Early Human Development, 2017;112():54-59. Early Human Development can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Early Human Development - www.journals.elsevier.com/early-human-development/)
Our news journalists report that additional information may be obtained by contacting O. Bozkurt, Zekai Tahir Burak Matern Teaching Hosp, Dept. of Neonatol, TR-06230 Ankara, Turkey. Additional authors for this research include N. Uras, F.N. Sari, F.Y. Atay, S. Sahin, A.D. Alkan, F.E. Canpolat and S.S. Oguz (see also Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency).
Keywords for this news article include: Ankara, Turkey, Eurasia, Nutritional and Metabolic Diseases and Conditions, Deficiency Diseases and Conditions, Clinical Trials and Studies, Vitamin D Deficiency, Nutrition Disorders, Clinical Research, Malnutrition, Avitaminosis, Department of Neonatology.
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