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Studies Conducted at University of Chinese Academy of Sciences on Alzheimer Disease Recently Reported [Androgen alleviates neurotoxicity of b-amyloid...

Pain & Central Nervous System Week

10-06-17

Studies Conducted at University of Chinese Academy of Sciences on Alzheimer Disease Recently Reported [Androgen alleviates neurotoxicity of b-amyloid peptide (Ab) by promoting microglial clearance of Ab and inhibiting microglial inflammatory ...]

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Alzheimer Disease. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Lower androgen level in elderly men is a risk factor of Alzheimer's disease (AD). It has been reported that androgen reduces amyloid peptides (Ab) production and increases Ab degradation by neurons."

Financial support for this research came from The Science & Technology Commission of Shanghai Municipality, China (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).

The news correspondents obtained a quote from the research from the University of Chinese Academy of Sciences, "Activated microglia are involved in AD by either clearing Ab deposits through uptake of Ab or releasing cytotoxic substances and pro-inflammatory cytokines. Here, we investigated the effect of androgen on Ab uptake and clearance and Ab-induced inflammatory response in microglia, on neuronal death induced by Ab-activated microglia, and explored underlying mechanisms. Intracellular and extracellular Ab were examined by immunofluorescence staining and Western blot. Amyloid peptides (Ab) receptors, Ab degrading enzymes, and pro-inflammatory cytokines were detected by RT-PCR, real-time PCR, and ELISA. Phosphorylation of MAP kinases and NF-kB was examined by Western blot. We found that physiological concentrations of androgen enhanced Ab uptake and clearance, suppressed Ab -induced IL-1b and TNFa expression by murine microglia cell line N9 and primary microglia, and alleviated neuronal death induced by Ab -activated microglia. Androgen administration also reduced Ab -induced IL-1b expression and neuronal death in murine hippocampus. Mechanistic studies revealed that androgen promoted microglia to phagocytose and degrade Ab through upregulating formyl peptide receptor 2 and endothelin-converting enzyme 1c expression, and inhibited Ab -induced pro-inflammatory cytokines expression via suppressing MAPK p38 and NF-kB activation by Ab , in an androgen receptor independent manner."

According to the news reporters, the research concluded: "Our study demonstrates that androgen promotes microglia to phagocytose and clear Ab and inhibits Ab -induced inflammatory response, which may play an important role in reducing the neurotoxicity of Ab."

For more information on this research see: Androgen alleviates neurotoxicity of b-amyloid peptide (Ab) by promoting microglial clearance of Ab and inhibiting microglial inflammatory response to Ab. Cns Neuroscience & Therapeutics, 2017;():. Cns Neuroscience & Therapeutics can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA. (Wiley-Blackwell - www.wiley.com/; Cns Neuroscience & Therapeutics - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1755-5949)

Our news journalists report that additional information may be obtained by contacting P.L. Yao, Key Laboratory of Food Safety Research, Chinese Academy of Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, People's Republic of China. Additional authors for this research include S. Zhuo, H. Mei, X.F. Chen, N. Li, T.F. Zhu, S.T. Chen, J.M. Wang, R.X. Hou and Y.Y Le.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/cns.12757. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Cns Neuroscience & Therapeutics is: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA.

Keywords for this news article include: Asia, Amyloid, Shanghai, Peptides, Proteins, Cytokines, Microglia, Neuroglia, Proteomics, Alzheimer Disease, Risk and Prevention, People's Republic of China, Neurodegenerative Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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