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Studies from University of Kentucky Update Current Data on Geriatrics and Gerontology (Hesperidin reverses perivascular adipose-mediated aortic...

Health & Medicine Week

10-06-17

Studies from University of Kentucky Update Current Data on Geriatrics and Gerontology (Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging)

By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Aging Research - Geriatrics and Gerontology is the subject of a report. According to news reporting out of Lexington, Kentucky, by NewsRx editors, research stated, "We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were assessed in C57BL/6 mice that were young (6 months), old (27-29 months), or old treated with hesperidin for 4 weeks."

Financial supporters for this research include National Institute of General Medicine Sciences, University of Kentucky (see also Aging Research - Geriatrics and Gerontology).

Our news journalists obtained a quote from the research from the University of Kentucky, "Old compared with young mice had increased aPWV (444 +/- 10 vs. 358 +/- 8 cm/s, P< 0.05) and mechanical stiffness (6506 +/- 369 vs. 3664 +/- 414 kPa, P< 0.05). In old mice hesperidin reduced both aPWV (331 +/- 38 cm/s) and mechanical stiffness (4445 +/- 667 kPa) to levels not different from young. Aortic segments from old animals cultured with (+) PVAT had greater mechanical stiffness compared to young (+) PVAT (6454 +/- 323 vs. 3575 +/- 440 kPa, P< 0.05) that was ameliorated in arteries from old hesperidin treated cultured (+) PVAT (2639 +/- 258 kPa). Hesperidin also reversed the aging-related PVAT AGE accumulation (all, P< 0.05). A 4week treatment with the AGE inhibitor aminoguanidine reversed both the age-related increase in aPWV (390 +/- 7 cm/s) and mechanical stiffness (3396 +/- 1072 kPa), as well as mechanical stiffness in arteries cultured (+) PVAT (3292 +/- 716 kPa) (all, P< 0.05) to values not different from young."

According to the news editors, the research concluded: "Hesperidin ameliorates the age-related increase in aortic stiffness and the PVAT-mediated effects on arterial stiffening. Hesperidin also reversed PVAT AGE accumulation, where PVAT AGE were shown to promote aortic stiffness with aging."

For more information on this research see: Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging. Experimental Gerontology, 2017;97():68-72. Experimental Gerontology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Experimental Gerontology - www.journals.elsevier.com/experimental-gerontology/)

Our news journalists report that additional information may be obtained by contacting B.S. Fleenor, University of Kentucky, Dept. of Kinesiol & Hlth Promot, Lexington, KY, United States. Additional authors for this research include T.B. Garner and A. Ouyang.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.exger.2017.08.003. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Lexington, Kentucky, United States, North and Central America, Geriatrics and Gerontology, Aging Research, University of Kentucky.

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