New Geriatrics and Gerontology Study Findings Have Been Reported by Researchers at University of Belgrade (Effects of Different Dietary Protocols on General Activity and Frailty of Male Wistar Rats During Aging)
By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Aging Research - Geriatrics and Gerontology is now available. According to news originating from Belgrade, Serbia, by NewsRx correspondents, research stated, "Dietary restriction (DR) is an important experimental paradigm for lifespan and healthspan extension, but its specific contribution regarding the type, onset and duration are still debatable. This study was designed to examine the impact of different dietary protocols by assessing the behavioral changes during aging."
Our news journalists obtained a quote from the research from the University of Belgrade, "We exposed male Wistar rats of various age to ad libitum (AL) or DR (60% of AL daily intake) feeding regimens with different onsets. The impact of DR on locomotor activity, memory and learning was examined in 12-, 18-and 24-month-old treated animals and controls using open field (OF) and Y maze tests. We have also evaluated the effects of different DR's through the quantification of animal frailty, using behavioral data to create the frailty score (FS). Our results indicated that dietary restriction improves general animal activity, spatial memory and decreases frailty with the effect being highly dependent on DR duration and onset. Notably, life-long restriction started at young age had the most profound effect. In contrast, shorter duration and later onset of restricted diet had significantly lower or no impact on animal's behavior and frailty."
According to the news editors, the research concluded: "This study signifies the importance of DR starting point and duration as critical determinants of DR effects on healthspan."
For more information on this research see: Effects of Different Dietary Protocols on General Activity and Frailty of Male Wistar Rats During Aging. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences, 2018;(): (see also Aging Research - Geriatrics and Gerontology).
The news correspondents report that additional information may be obtained from S. Todorovic, Dept. of Neurobiology, Institute for Biological Research 'Sinisa Stankovic', University of Belgrade, Belgrade, Serbia. Additional authors for this research include K. Smiljanic, S. Ruzdijic, A. Mladenovic Djordjevic and S. Kanazir.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1093/gerona/gly015. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Serbia, Europe, Belgrade, Aging Research, Geriatrics and Gerontology.
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