Research Data from Capital Medical University Update Understanding of Caloric Restriction (Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Diet and Nutrition - Caloric Restriction. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Caloric restriction (CR) is effective in slowing aging and delaying aging-related diseases in many species, but the mechanism is complex and not fully elucidated. This study aimed to evaluate the beneficial effects of a caloric restriction diet on learning and memory, and further to elucidate the mechanisms."
Funders for this research include National Natural Science Foundation of China, Beijing Natural Science Foundation (see also Diet and Nutrition - Caloric Restriction).
The news correspondents obtained a quote from the research from Capital Medical University, "Thirty-six week-old male C57/BL mice were randomly divided into three groups: normal control (NC group), high-energy (HE group) and CR group. After 44 weeks, the Morris water maze was used to examine learning and memory abilities. Western blotting and immunohistochemistry were used to detect changes in proteins involved in the adenosine mono-phosphate-activated protein kinase (AMPK) pathway in the mouse hippocampus. Compared with NC group, the swimming distance and escape latency were shorter in the CR group. The protein and mRNA expression of AMPK and glucose transporter type 4 (GLUT4) in the CR group were significantly higher than that in HE group. CR increased serum insulin-like growth factor, adiponectin and vaspin, decreased blood glucose and serum malondialdehyde, and improved insulin sensitivity."
According to the news reporters, the research concluded: "Our findings demonstrate that a CR diet may improve hippocampus-dependent spatial learning ability of C57/BL mice, accompanied with an increase in AMPK and GLUT4 expression, which indicates AMPK pathway was associated with the neuroprotective effect of CR in mice."
For more information on this research see: Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway. Experimental Gerontology, 2018;102():28-35. Experimental Gerontology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Experimental Gerontology - www.journals.elsevier.com/experimental-gerontology/)
Our news journalists report that additional information may be obtained by contacting R. Wang, Capital Med Univ, Beijing Inst Brain Disorders, Xuan Wu Hosp, Cent LabKey Lab Neurodegenerat DisMinist EducC, Beijing 100053, People's Republic of China. Additional authors for this research include L.N. Ma, W. Dong and Z.W. Zhao.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.exger.2017.11.013. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Beijing, People's Republic of China, Asia, Health and Medicine, Caloric Restriction, Diet and Nutrition, Peptide Proteins, Peptide Hormones, Proinsulin, Capital Medical University.
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