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Data from Jining Medical University Advance Knowledge in Lipopolysaccharides (Fish oil supplementation attenuates neuroinflammation and alleviates...

Drug Week

04-13-18

Data from Jining Medical University Advance Knowledge in Lipopolysaccharides (Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide)

By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Biological Factors - Lipopolysaccharides. According to news originating from Jining, People's Republic of China, by NewsRx correspondents, research stated, "Depression is frequently associated with inflammation, whereas omega-3 polyunsaturated fatty acids (PUFAs) primarily found in fish oil possess anti-inflammatory properties. Although converging studies suggest an antidepressant effect of PUFAs, there is limited evidence directly linking the neuro-immune modulating features of PUFAs to the antidepressant actions."

Financial supporters for this research include Tianjin Municipal Education Commission, National Natural Science Foundation of China (see also Biological Factors - Lipopolysaccharides).

Our news journalists obtained a quote from the research from Jining Medical University, "Therefore, we assessed the effects of fish oil (FO) supplementation on behavioral changes, inflammatory cytokine expression and oxidative reactions in frontal cortex and hippocampus of rats following repeated peripheral immune challenge by lipopolysaccharide (LPS) for 2 weeks (500 mu g/kg every other day). Repeated LPS administration induced the rats to a depressive-like state and increased mRNA expression of pro-inflammatory cytokines, including 1L-1 beta, 1L-6 and TNF-alpha, in frontal cortex and hippocampus. FO supplementation attenuated the LPS-induced abnormal behavior and brain inflammatory response. Concurrent with the antidepressant action, FO also reduced LPS-induced oxidative reactions and neural apoptosis in the rat brain, as evidenced by decreased malondialdehyde (MDA) production, increased catalase activities and inhibited pro-apoptotic protein Bax mRNA expression. In addition, FO inhibited activation of NF-kappa B and iNOS induced by LPS. Interestingly, we found FO suppressed the activation of the inflammasome NLRP3 and ionotropic purinergic receptor P2X7R evoked by LPS, suggesting a potential anti-inflammatory mechanism for PUFAs. Besides, FO also restored the LPS-induced neurochemical disturbance, especially the balance between serotonin and kynurenine branches of tryptophan metabolism, which is tightly associated with depression."

According to the news editors, the research concluded: "These findings provide novel insights into the antidepressant action of PUFAs and further strengthen the link between inflammation and depression."

For more information on this research see: Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide. European Journal of Nutrition, 2018;57(3):893-906. European Journal of Nutrition can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; European Journal of Nutrition - www.springerlink.com/content/1436-6207/)

The news correspondents report that additional information may be obtained from P. Jiang, Jining Med Univ, Jining Peoples Hosp 1, Inst Clin Pharm & Pharmacol, Jining 272000, People's Republic of China. Additional authors for this research include X.Y. Zhou, M.M. Tang, P.F. Xu, X.X. Gong, Y.Y. Liu, H.X. Jiao and R.L. Dang.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s00394-016-1373-z. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Jining, People's Republic of China, Asia, Bacterial Polysaccharides, Lipopolysaccharides, Drugs and Therapies, Biological Factors, Bacterial Toxins, Antidepressants, Endotoxins, Jining Medical University.

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