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Al-Azhar University Reports Findings in Biomarkers (L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative...

Obesity, Fitness & Wellness Week

04-13-18

Al-Azhar University Reports Findings in Biomarkers (L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines)

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Diagnostics and Screening - Biomarkers. According to news originating from Cairo, Egypt, by NewsRx correspondents, research stated, "UVA comprises more than 90% of the solar UV radiation reaching the Earth. Artificial lightening lamps have also been reported to emit significant amounts of UVA."

Our news journalists obtained a quote from the research from Al-Azhar University, "Exposure to UVA has been associated with dermatological disorders including skin cancer. At the molecular level, UVA damages different cellular biomolecules and triggers inflammatory responses. The current study was devoted to investigate the potential protective effect of L-carnitine against UVA-induced skin tissue injury using rats as a mammalian model. Rats were distributed into normal control group (NC), L-carnitine control group (LC), UVA-Exposed group (UVA), and UVA-Exposed and L-carnitine-treated group (UVA-LC). L-carnitine significantly attenuated UVA-induced elevation of the DNA damage markers 8-oxo-2'-deoxyguanosine (8-oxo-dG) and cyclobutane pyrimidine dimers (CPDs) as well as decreased DNA fragmentation and the activity of the apoptotic marker caspase-3. In addition, L-carnitine substantially reduced the levels of lipid peroxidation marker (TBARS) and protein oxidation marker (PCC) and significantly elevated the levels of the total antioxidant capacity (TAC) and the antioxidant reduced glutathione (GSH) in the skin tissues. Interestingly, L-carnitine upregulated the level of the DNA repair protein proliferating cell nuclear antigen (PCNA). Besides it mitigated the UVA-induced activation of the oxidative stress-sensitive signaling protein p38 and its downstream target c-Fos. Moreover, L-carnitine significantly downregulated the levels of the early response proinflammatory cytokines TNF-alpha, IL-6, and IL-1 beta."

According to the news editors, the research concluded: "Collectively, our results highlight, for the first time, the potential attenuating effects of L-carnitine on UVA-induced skin tissue injury in rats that is potentially mediated through suppression of UVA-induced oxidative stress and inflammatory responses."

For more information on this research see: L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines. Chemico-Biological Interactions, 2018;285():40-47. Chemico-Biological Interactions can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Chemico-Biological Interactions - www.journals.elsevier.com/chemico-biological-interactions/)

The news correspondents report that additional information may be obtained from S.A. Salama, Al Azhar Univ, Dept. of Biochem, Fac Pharm, Cairo 11751, Egypt. Additional authors for this research include H.H. Arab, H.A. Omar, H.S. Gad, G.M. Abd-Allah, I.A. Maghrabi and M.M. Al Robaian (see also Diagnostics and Screening - Biomarkers).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.cbi.2018.02.034. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Cairo, Egypt, Africa, Intercellular Signaling Peptides and Proteins, Trimethyl Ammonium Compounds, Diagnostics and Screening, Health and Medicine, Biomarkers, Cytokines, Carnitine, Al-Azhar University.

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