Life Changing Clinical Trials Take Honours at National Awards
Targeted News Service
Finalist was the PRECISE trial led by the
Winner of Trial of the Year was the Australian Placental Transfusion Study that discovered that delayed clamping of the umbilical cord in preterm infants cuts the relative risk of death by a third.
Importantly, both trials have led to changes in clinical practice leading to life-changing, life-saving benefits in tens of thousands of people globally.
" Despite pregabalin's widespread use, until the PRECISE trial there was limited evidence informing its use for sciatica. "
The PRECISE trial
The PRECISE trial, published last year in
"The trial found that taking pregabalin did not reduce the severity of leg pain, or improve other health outcomes, compared to placebo in the treatment of sciatica," said the study's senior author, Associate Professor
"However, trial participants who took pregabalin had a higher risk of unwanted effects such as dizziness. These findings are significant for patient care and clinical practice because they provide strong evidence that this common medicine should be avoided in people with sciatica."
The PRECISE trial was the first to rigorously examine the efficacy of pregabalin in sciatica and the findings do not support its continued use for this condition.
"Despite pregabalin's widespread use, until the PRECISE trial there was limited evidence informing its use for sciatica," says Dr
"Support for using pregabalin was based on its success in other pain conditions, such as nerve pain experienced by people with diabetes. The PRECISE trial has caused us to rethink its use in sciatica. We're really excited that our trial was selected as a finalist in these prestigious awards, as this really helps us to share the important findings."
Importantly, the findings of the PRECISE Trial will influence practice and change clinical guidelines ensuring the results of high quality clinical trials are meaningfully used to improve outcomes for patients.
Australian Placental Transfusion Study
Is there harm or benefit in delayed clamping of the umbilical cord in preterm infants?
The first evidence, published in the
" As a result of the Australian Placental Transfusion Study, we can say that delayed clamping of the umbilical cord by 60 seconds saves preterm babies' lives. "
The largest of these trials was the Australian Placental Transfusion Study involving nearly 1,600 babies born more than ten weeks early in 25 hospitals in seven countries.
In that trial, led by the
"Ten years ago, umbilical cords were routinely clamped quickly after a preterm birth and the baby was passed to a paediatrician in case s/he needed urgent help with breathing," says
"But we now know that almost all preterm babies will start breathing by themselves in the first minute, if they are given time."
"As a result of the Australian Placental Transfusion Study, we can say that delayed clamping of the umbilical cord by 60 seconds saves preterm babies' lives. It also means that fewer babies get blood transfusions, and there is no increase in complications for mother or baby."
" This intervention is simple and can be applied in every setting where babies are born across the world. This research will save lives. "
Why does delayed clamping benefit preterm babies?
"First, babies may get extra red and white blood and stem cells from the placenta, helping to achieve healthy oxygen levels, control infection and repair injured tissue," says Professor Tarnow-Mordi.
"Second, they get more time to start breathing on their own, helping them avoid invasive procedures.
"Worldwide, the benefits are huge because 15 million babies are born preterm each year. Fast, effective treatments that cost nothing are rare, but the evidence shows that delayed cord clamping is one of them."
"We estimate that for every thousand very preterm babies born more than ten weeks early, delayed clamping will save between 20 and 100 additional lives compared with immediate clamping," said the
"This means that, worldwide, using delayed clamping instead of immediate clamping can be expected to save between 11,000 and 100,000 additional lives every year."
Research co-author and Professor of Obstetrics and Gynaecology, Dr
"This intervention is simple and can be applied in every setting where babies are born across the world. This research will save lives."
For babies who don't need immediate resuscitation the message is simple - wait a minute!
Information for parents
Parents who want to know more are encouraged to visit the NHMRC Clinical Trials Centre website at http://www.ctc.usyd.edu.au or