New Data from Imperial College London Illuminate Findings in Thrombosis (The Isothiocyanate Sulforaphane Modulates Platelet Function and Protects Against Cerebral Thrombotic Dysfunction)
By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Cardiovascular Diseases and Conditions - Thrombosis have been presented. According to news reporting out of London, United Kingdom, by NewsRx editors, research stated, "Platelet activation provides a critical link between inflammation and thrombosis. Sulforaphane (SFN), a naturally occurring isothiocyanate, has been shown to display both anti-inflammatory and anti-thrombotic actions in the systemic microvasculature."
Our news journalists obtained a quote from the research from Imperial College London, "As inflammation promotes thrombosis and vice versa, this study investigates whether SFN is able to reduce inflammatory potentiation of thrombotic events, suppress platelet activation and thrombus formation in the cerebral microvasculature. Thrombosis was induced in the murine brain using the light/dye-injury model, in conjunction with lipopolysaccharide (LPS) treatment, with and without SFN treatment. In vitro and in vivo platelet assays (aggregation, flow and other functional tests) were also employed, using both human and murine platelets. SFN was found to reduce LPS mediated enhancement of thrombus formation in the cerebral microcirculation. In tail bleed experiments LPS treatment prolonged bleeding time, and SFN treatment was found to protect against this LPS-induced derangement of platelet function. SFN inhibited collagen-mediated platelet aggregation in vitro and in vivo and the associated adhesion and impaired calcium signalling. Furthermore, Glycoprotein VI (GPVI) is involved in the protective effects observed with SFN treatment."
According to the news editors, the research concluded: "Data presented here provides evidence for the use of SFN in preventing stroke in selected high-risk patient cohorts."
For more information on this research see: The Isothiocyanate Sulforaphane Modulates Platelet Function and Protects Against Cerebral Thrombotic Dysfunction. British Journal of Pharmacology, 2018;():. British Journal of Pharmacology can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. (Wiley-Blackwell - www.wiley.com/; British Journal of Pharmacology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1476-5381)
Our news journalists report that additional information may be obtained by contacting S. Gillespie, Division of Brain Sciences, Imperial College London, London, UK. Additional authors for this research include P.M. Holloway, F. Becker, F. Rauzi, S.A. Vital, K.A. Taylor, K.Y. Stokes, M. Emerson and F.NE Gavins (see also Cardiovascular Diseases and Conditions - Thrombosis).
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/bph.14368. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Publisher contact information for the British Journal of Pharmacology is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA.
Keywords for this news article include: London, Europe, Hematology, Isocyanates, Inflammation, United Kingdom, Isothiocyanates, Sulfur Compounds, Blood Transfusion, Health and Medicine, Transfusion Medicine, Embolism and Thrombosis, Cardiovascular Diseases and Conditions.
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