Life Extension Update
Cysteine recommended for digestive tract cancer prevention
Researchers at the University of Helsinki in Finland have suggested the addition of the amino acid L-cysteine to tablets and chewing gum to help prevent upper digestive tract cancers. Cysteine can help protect against mouth, pharynx and esophageal cancers due to its ability to neutralize the effects of acetaldehyde, a compound formed when people drink alcohol or smoke. Smoking and drinking is believed to be responsible for up to 80 percent of upper digestive tract cancers.
While L-cysteine tablets or gum can help eliminate acetaldehyde from the upper digestive tract, the carcinogen can also be produced in the stomach by the action of oral microbes on foods with a high sugar or carbohydrate content, particularly among individuals who produce insufficient hydrochloric acid, a condition associated with an increased risk of gastric cancer. Other products that contain L-cysteine are being developed that will slowly release the amino acid in different parts of the gastrointestinal tract, so that acetaldehyde can be eliminated in the stomach or intestine.
N-acetyl-cysteine (NAC) is the acetylated precursor of the amino acids L-cysteine and reduced glutathione. Historically, it is used as a mucolytic agent in respiratory illnesses as well as an antidote for acetaminophen hepatotoxicity, but more recently its credits have grown. Animal and human studies have shown it to be a powerful antioxidant and a potential therapeutic agent in the treatment of cancer (Bongers et al. 1995; van Zandwijk 1995).
The biological value of NAC is attributed to its sulfhydryl group, while its acetyl-substituted amino group offers protection against oxidative and metabolic processes (Bonanomi et al. 1980; Sjodin et al. 1989). In vitro studies showed NAC to be directly antimutagenic and anticarcinogenic; in vivo, NAC inhibited mutagenicity of a number of mutagenic materials (De Flora et al. 1986, 1992). NAC has both chemopreventive and therapeutic potential in malignancies arising in the lung, skin, breast, liver, head, and neck (van Zandwijk 1995; Izzotti 1998).
NAC is effective in inhibiting tumor cell growth in melanoma, prostate cells, and astrocytoma cell lines (the latter is a primary tumor in the brain) (Albini et al. 1995; Arora-Kuruganti et al. 1999; Chiao et al. 2000). Neovascularization (new blood vessel growth) is crucial for tumor mass expansion and metastasis. NAC inhibited invasion and metastasis of malignant cells by up to 80% by preventing angiogenesis (De Flora et al. 1996).
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