The 121st Annual Meeting of the American Physiological Society (part of the Experimental Biology 2008 scientific conference) was the site of a presentation by Jain-Wei Gu of the Department Physiology & Biophysics at the University of Mississippi Medical Center in Jackson, who reported that giving mice an antioxidant polyphenol found in green tea helped prevent the growth of breast tumors.
Dr Gu, along with University of Mississippi colleagues Emily Young, Jordan Covington, James Wes Johnson, and Wei Tan, added epigallocatechin-3-gallate (EGCG) from green tea to the drinking water of seven week old female mice for five weeks, while a control group received unenhanced drinking water. During the second week of the study, the animals received injections of mouse breast cancer cells into one of their mammary glands.
At the end of the treatment period, tumor weights, cross section area, intratumor microvessel density (which evaluates angiogenesis, the formation of new blood vessels), and vascular endothelial growth factor (VEGF, found in various cancers) protein levels were measured. Mice that received EGCG had an average of 66 percent smaller tumor cross section areas, 68 percent lower tumor weight, and lower microvessel density and VEGF protein levels in their tumors and plasma than mice that did not receive the polyphenol.
Dr Gu suggested that EGCG works by directly targeting tumor blood vessels via suppression of angiogenesis, as well as targeting tumor cells by helping to prevent their proliferation and migration.
“In this study we have demonstrated that the frequent ingestion of EGCG significantly inhibits breast tumor growth, VEGF expression and tumor angiogenesis in mice,” Dr Gu concluded. “We believe our findings will help lead to new therapies for the prevention and treatment of breast cancer in women.”
According to the National Cancer Institute, solid tumors cannot grow beyond the size of a pinhead, that is, 1-2 cubic mm, without inducing the formation of new blood vessels to supply the nutritional needs of the tumor. Since rapid vascularization and tumor growth appear to occur concurrently, interrupting the vascular growth cycle is paramount to overcoming the malignancy.
Tumor angiogenesis results from a cascade of molecular and cellular events, usually initiated by the release of angiogenic growth factors. At a critical phase in the growth of a tumor, the tumor sends out signals to nearby endothelial cells to activate new blood vessel growth. The pro-angiogenic growth factors diffuse in the direction of preexisting blood vessels, encouraging development (Folkman 1992 b; Folkman et al. 1992 a).
Various agents are known to activate endothelial cell growth, including angiogenin, estrogen, interleukin-8, fibroblast growth factors (both acidic and basic), prostaglandin E2, tumor necrosis factor, granulocyte colony-stimulating factor, and VEGF. VEGF and basic fibroblast growth factors are expressed by many tumors and appear particularly important to tumor development and angiogenesis (NIH/NCI 1998)
A number of substances from orthodox and natural pharmacology (angiostatin, endostatin, interferons, interleukin-2, curcumin, green tea, lactoferrin, N-acetyl-cysteine (NAC), resveratrol, grape seed-skin extract, retinoic acid (vitamin A), and vitamin D) are antiangiogenic in nature. Endostatin, a fragment of collagen XVIII, and angiostatin, a fragment of plasminogen involved in the coagulation process, have produced remarkable results in animal models.
During our annual Blood Test Super Sale, members save up to 80% compared to the retail prices charged by other blood testing labs.
For the first time, Life Extension members can obtain the comprehensive Male or Female Blood Test Panels for only $198. These same tests can cost over $1,000 at other laboratories, but are being offered to members at this previously unheard of low price until June 2, 2008. In addition, Life Extension is now offering a vitamin D blood test for only $25) when you purchase a comprehensive Male or Female Panel that is 50% below our low retail price, and about 80% below what commercial labs charge. Since vitamin D deficiency occurs most commonly during the winter months when the majority of Americans do not receive adequate sunlight, spring is the ideal time to check your vitamin D status.
Natural Weight Loss is a stimulant-free formula that includes Neuravena™ Bio-Assay Green Oat Extract to reduce the desire to emotionally overeat.
Korean pine nuts contain the highest concentration of pinolenic acid of any species of pine nut in the world. The vegetable sourced pinolenic acid helps to suppress appetite by stimulating the appetite controlling hormone cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) in the gastrointestinal tract.
Adenosine triphosphate (ATP) is a critical component of the cellular energy cycle. When administered orally to rabbits, ATP increased blood flow, reduced vascular resistance, and increased arterial oxygen pressure. In baboons, ATP infusions increased cerebral blood flow by nearly 50 percent and boosted oxygen consumption in the brain.
Peak ATP™ is a patented brand of ATP that has been tested in human and animal studies. Peak ATP™ is readily absorbed and boosts circulating ATP levels. Red blood cells release ATP to produce endothelial vasodilation, or widening of the arteries. Ensuring adequate red blood cell pools of ATP to help regulate vascular tone is critical to maintaining circulatory health.