A study conducted by Dean Ornish, MD, of the Preventive Medicine Research Institute in Sausalito, California, along with researchers at the University of California, San Francisco, found that lifestyle improvements have a beneficial effect on gene expression in men with prostate cancer. The finding was reported in the June 17, 2008 issue of the Proceedings of the National Academy of Sciences.
The investigation involved 30 participants in the Gene Expression Modulation by Intervention with Nutrition and Lifestyle (GEMINAL) study of men with low-risk prostate cancer. For reasons not related to the study, the men had opted for active surveillance of their disease in lieu of surgery or radiation treatment. For a three month period, participants were ask to limit dietary fat to 10 percent of daily calorie intake, adopt a whole food, plant-based diet, engage in 30 minutes per day of walking for six days per week, and practice stress management in the form of stretching, breathing, meditation, imagery and relaxation for 60 minutes per day in addition to a one hour per week group session. Diets were supplemented daily with tofu (from soy), soy protein, 3 grams fish oil, 200 micrograms selenium, 2 grams vitamin C and 100 international units vitamin E. Cardiovascular disease risk factors, including weight, body mass index, waist circumference, blood pressure, lipids, and C-reactive protein, were measured before and after the intervention.
Gene expression in initial prostate biopsies was compared with prostate tissue samples obtained after three months of the lifestyle changes. Forty-eight genes, including those that have disease-preventive effects, were found to be up-regulated, and 453 genes, including oncogenes involved in breast and prostate cancer and other disease-promoting genes, were down-regulated following the intervention. Body mass index, systolic and diastolic blood pressure, lipids and waist circumference significantly improved. Benefits of the regimen were also observable in the participants’ mental health-related quality of life and levels of cancer-associated mental distress.
“Intensive nutrition and lifestyle changes may modulate gene expression in the prostate,” the authors conclude. “Understanding the prostate molecular response to comprehensive lifestyle changes may strengthen efforts to develop effective prevention and treatment. Larger clinical trials are warranted to confirm the results of this pilot study.”
Out of every 100 men diagnosed with prostate cancer (PC), approximately 5 will have hereditary PC (HPC). HPC is presently defined by any one of the following three criteria:
Three successive generations with members having PC
Three first-degree relatives, for example, a father and two brothers, three brothers, or a father and two sons with PC
Two relatives with PC diagnosed before age 55
It is not surprising that the incidence of hereditary breast cancer is also about 5% of the total population of breast cancer patients--the same incidence as that of HPC.
HPC is transmitted by a gene from father to son and from father to daughter and then to her son. When HPC is present, nearly half the male offspring will have PC, and many of these will develop PC before age 55. In fact, HPC accounts for approximately 43% of PC diagnosed before the age of 55 years.
Since the transmission of the gene may also occur from father to daughter and then to her son, a sound medical history includes information about the health of the maternal grandfather as well as maternal uncles and maternal cousins regarding any history of PC. Studies of PC within families show a stronger familial inheritance pattern than colon or breast cancer.
It should also be emphasized that men with a history of breast cancer (BC) in their family are also at greater risk for developing PC, just as women with a family history of PC are at greater risk for developing BC.
Last call for Fountain of Life Alaskan Cruise at Life Extension group rates!
Come aboard with us on Celebrity’s sumptuous Infinity for Life Extension’s 2nd Annual “Fountain of Life” Cruise! Immerse yourself in the breathtaking beauty of Alaska’s wilderness while you learn the latest secrets to living a longer, healthier life! Witness the awesome spectacle of Hubbard’s Glacier while you discover the newest ways to fight old age and disease! Enjoy scenic ports of call like Sitka, Juneau, Ketchikan and Victoria, British Columbia, while you put yourself on the road to greater health and longevity!
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Travel press, such as Condé Nast Traveler, consistently rate Celebrity Cruises as one of the world's finest cruise lines. Celebrity offers an incomparable cruise experience aboard ships of uncompromising style and sophistication. From spectacular dining to indulgent spa treatments, you’ll find countless possibilities to satisfy body and soul. Sleep upon Egyptian cotton linens, enjoy butler service in all suites, or special amenities with Concierge Class staterooms, dine in award-winning restaurants, pay a visit to Fortunes Casino, experience Las Vegas-style shows or a movie in the cinema, be pampered by Celebrity's exclusive AquaSpa programs, and much more.
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Many instructors and fitness enthusiasts are switching from long slow exercise sessions to short fast ones. Now available for the first time through Life Extension is a fast-twitch DVD routine called the No Excuses Workout™ (NEW) developed by award-winning fitness pioneer, John Abdo. NEW is a fast-twitch total body routine that's completed in only seven minutes. It requires no equipment and can be performed almost anywhere you like: home, office or hotel room, hence the title No Excuses.
The DVD begins with a complete demonstration of each exercise offering detailed instruction. Press skip on the menu and you jump right into the actual 7 minute routine to tone every muscle in your body, boost your cardio-respiratory conditioning, and burn loads of fat.
FernBlock® is an oral supplement designed to help protect against harmful solar radiation. In over a decade of clinical trials, FernBlock® has shown remarkable effectiveness in shielding skin against dangerous ultraviolet exposure. Studies have shown that this fern extract has a high affinity for skin tissue and helps protect against ultraviolet damage shown to cause premature skin aging, wrinkling, and DNA-related skin mutations.
FernBlock® is a natural extract derived from the fern plant Polypodium leucotomos, which has been used as a sunburn remedy by native Indians for centuries. For the first time, researchers have created a unique oral formulation of sun-protective compounds from this natural extract.