Protective effect found for ginkgo against radiation damage
A report published in the October 11, 2009 issue of the International Journal of Low Radiation added evidence to a protective effect for Ginkgo biloba against radiation damage. Ginkgo biloba is a tree species whose leaves have been used for centuries in Chinese medicine. Ginkgo leaf extract contains antioxidant compounds called ginkgolides and bilobalides which help scavenge free radicals that attack nearly all components of the cell, including DNA.
In their article, Chang-Mo Kang of the Korea Institute of Radiological and Medical Sciences in Taegu and colleagues describe their use of an assay for radiation-induced programmed cell death (apoptosis) to evaluate the protective effect of ginkgo extract against radiation exposure that occurs during accidents or occupational overexposure. In one experiment, white blood cells from human donors aged 18 to 50 were treated with one of four concentrations of ginkgo extract or a 9 percent saline solution before being exposed to gamma rays.
The researchers found a significant dose-dependent reduction in apoptotic cells among those treated with ginkgo. While radiation-induced apoptosis occurred in nearly one third of irradiated cells not treated with ginkgo, the number declined to 5 percent or less in cells treated with the herb.
In another experiment, mice were treated with ginkgo extract or saline before and after receiving whole body ionizing radiation. Mice that did not undergo radiation served as controls. Examination of the animals' spleens found that treatment with ginkgo maintained organ size comparable with that of animals that did not receive radiation, while spleens in irradiated animals that did not receive ginkgo were significantly smaller.
In their discussion of the findings, the authors note that cell-damaging free radicals and reactive oxygen species can be generated in excess under numerous conditions, including exposure to environmental chemicals, specific drugs, and during normal aging.
"These results indicate that the radioprotective effects of ginkgo extracts administered prior to radiation are due to the OH radical scavenging activity," the authors write. "Therefore, ginkgo extract should be useful for the protection of radiosensitive organs against free radicals.
A well-justified fear of cancer is a major reason why people take dietary supplements. As has already been shown, there is a compelling body of evidence that cancer risk can be reduced by taking the proper supplements over an extended period of time.
An article in the Journal of the American Medical Association (JAMA) by Clark et al. (1996) showed that 200 mcg of supplemental selenium a day reduced overall cancer mortality by 50% in humans compared to a placebo group not receiving supplemental selenium. This 9-year study demonstrated that a low-cost mineral supplement could cut the risk of dying from cancer in half in certain individuals.
In the March 17, 1999, issue of the Journal of the National Cancer Institute (Zhang et al. 1999), associations between intakes of specific nutrients and subsequent breast cancer risk were investigated in 83,234 women who were participating in the Harvard Nurses' Health Study. Breast cancer risks were significantly lower in women who consumed alpha-carotene, beta-carotene, lutein/zeaxanthin, and vitamins A and C. Among premenopausal women who consumed moderate amounts of alcohol (a known risk factor in breast cancer), beta-carotene lowered risk. Premenopausal women who consumed 5 or more servings a day of fruits and vegetables had modestly lower risk of breast cancer than those who had less than 2 servings a day.
Life Extension Pharmacy Get $25 toward Life Extension supplements with your first new or transferred prescription to Life Extension Pharmacy
Shopping around for low prices on generic drugs? Let Life Extension Pharmacy™ be the “one-stop” source for all your low-cost prescription medication needs, including customized prescription compounding. Life Extension Pharmacy is dedicated to improving the benefits customers receive from prescription drugs while dramatically reducing the cost.
You can easily transfer your prescriptions to the Life Extension Pharmacy or place an order by calling toll-free at 1-877-877-9700 and speaking to one of our knowledgeable pharmacy staff. Or call 1-877-877-9707 to use our after-hours refill line and leave your prescription information to be refilled the next business day. You can also visit us online at www.LifeExtensionRx.com for our 24-hour prescription transfer and refill service.
Do the right thing for your health — and pocketbook. Call or visit us online and start saving today!
Life Extension® the global authority on nutrition, health and wellness, as well as a provider of scientific information on anti-aging supplements and therapies, has introduced Glutathione, Cysteine & C product formulated with 50 mg of Setria® Glutathione from Kyowa Hakko USA.
Glutathione (gamma-L-glutamyl-L-cysteinyl-glycine) is a peptide-like (short-protein) molecule synthesized in the body from the three amino acids: L-glutamic acid, L-cysteine and glycine. Glutathione is one of the body’s most important and powerful antioxidants helping to detoxify xenobiotics. A major function of vitamin C is to keep glutathione in its reduced form so it can continue to provide free radical-quenching affects.
L-cysteine is a conditionally essential amino acid, one of only three sulfur-containing amino acids, the others being taurine (which can be produced from L-cysteine) and L-methionine from which L-cysteine can be produced in the body by a multi-step process. Cysteine plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification and as a methyl donor in the conversion of homocysteine to methionine. Cysteine also helps synthesize glutathione, one of the body’s most important natural detoxifiers.
Kyowa Hakko USA, with offices located in New York and California, offers manufacturers and formulators one of the industry's most extensive lines of over 50 amino acids and related compounds, including D-Amino acids and branched-chain amino acids, as well as nucleic acids, bio-products and fine chemicals.
Milk thistle extract has long been valued for its role in ensuring healthy liver function, and it is also a powerful antioxidant. Milk thistle extract consists of silibinin and other similar compounds. Until recently, scientists focused their research on silibinin, as it was the most abundant and biologically active ingredient found in milk thistle extract. Highly advanced extraction technology has now enabled scientists to isolate other silymarin constituents and to test their efficacy against various cell lines. Among the compounds tested, a silymarin constituent called isosilybin B proved to be the most efficient in maintaining healthy cell division.
Mega Silymarin with Isosilybin B is the first milk thistle extract to contain standardized, premium-quality potencies of silymarin, silibinin and isosilybin B, providing the full spectrum of milk thistle compounds that promote a healthy liver and prostate.
The botanical extract in Mega Silymarin is a triple standardized milk thistle extract. In addition to an optimal 80% standardization of the main active compounds, silymarin flavonolignans, Mega Silymarin is further standardized to two highly active isomers—silibinin and isosilybin B. Most premium milk thistle extracts are devoid of or lack consistent amounts of the most active flavonolignan isomer isosilybin B.