Multinutrient supplement reduces age-related decline in activity level in mice
An article published in the January, 2010 issue of the journal Experimental Biology and Medicine reveals the discovery by researchers at McMaster University in Hamilton, Ontario that administering a combination of nutrients to mice delays the decline in activity that occurs with aging. Their finding adds to previous research showing that the supplement combo modestly extends life span, aids in the prevention of cognitive decline, and helps protect against radiation.
Associate professor of biology C. David Rollo and colleagues used a formula consisting of the following nutrients: vitamins B1, B3, B6, B12, C, D and E, folic acid, beta-carotene, acetyl-L-carnitine, alpha-lipoic acid, acetylsalicylic acid, bioflavonoids, chromium picolinate, garlic, ginger root extract, Ginkgo biloba, ginseng, green tea extract, L-glutathione, magnesium, manganese, melatonin, N-acetylcysteine, potassium, rutin, selenium, cod liver oil, coenzyme Q10 and flax seed oil. Many of these nutrients have antioxidant benefits, which some researchers believe could help forestall a variety of age-related diseases and conditions. The supplement combination was given from the time of weaning to 9 normal mice and 11 transgenic mice that exhibited reduced motor activity and accelerated aging. Equal numbers of control animals received unsupplemented diets.
While normal mice that did not receive the nutritional cocktail experienced a greater than 50 percent reduction in daily movement by 24 months of age, those that received the supplements maintained youthful levels of activity. Unsupplemented mice experienced increased declines in mitochondrial function and in brain signaling chemicals related to movement compared to supplemented mice, and showed increased oxidative injury. Untreated transgenic mice had reduced activity levels at all ages, yet those that were supplemented had an approximately 45 percent greater level of activity at 4 months compared to untreated animals.
"As we all eventually learn, aging diminishes our mind, fades our perception of the world and compromises our physical capacity," Dr Rollo remarked. "Declining physical activity—think of grandparents versus toddlers—is one of the most reliable expressions of aging and is also a good indicator of obesity and general mortality risk."
"For aging humans maintaining zestful living into later years may provide greater social and economic benefits than simply extending years of likely decrepitude," he added. "This study obtained a truly remarkable extension of physical function in old mice, far greater than the respectable extension of longevity that we previous documented. This holds great promise for extending the quality of life of 'health span' of humans."
"Although identifying the role of specific ingredients and interactions remains outstanding, results provide proof of principle that complex dietary cocktails can powerfully ameliorate biomarkers of aging and modulate mechanisms considered ultimate goals for aging interventions," the authors conclude.
The premise of taking actions to maintain youthful health and vigor is based on findings from peer-reviewed scientific studies that identify specific factors that cause us to develop degenerative disease. These studies suggest that the consumption of certain foods, food extracts, hormones, or drugs will help to prevent common diseases that are associated with normal aging.
Therefore, the concept of disease prevention can be defined as the incorporation of findings from published scientific studies into a logical daily regimen that enables an individual to attain optimal health and longevity.
For the greater part of the 20th century, mainstream medicine was openly hostile to the idea of healthy people taking vitamin supplements. This antivitamin position began to change in the 1990s as irrefutable evidence emerged that supplements could reduce the risk of age-related disease without inducing toxicity.
In the April 9, 1998, issue of the New England Journal of Medicine, an editorial was entitled "Eat Right and Take a Multi-Vitamin." This article was based on studies indicating that certain supplements could reduce homocysteine serum levels and therefore lower heart attack and stroke risk. This was the first time this prestigious medical journal recommended vitamin supplements (Oakley 1998).
An even stronger endorsement for the use of vitamin supplements was in the June 19, 2002, issue of the Journal of the American Medical Association (JAMA). According to the Harvard University doctors who wrote the JAMA guidelines, it now appears that people who get enough vitamins may be able to prevent such common illnesses as cancer, heart disease, and osteoporosis. The Harvard researchers concluded that suboptimal levels of folic acid and vitamins B6 and B12 are a risk factor for heart disease and colon and breast cancers; low levels of vitamin D contribute to osteoporosis; and inadequate levels of the antioxidant vitamins A, E, and C may increase the risk of cancer and heart disease (Fairfield et al. 2002).
Lycopene may be an important substance in maintaining prostate health. A recent clinical trial demonstrated that lycopene at a dose of 15 mg per day can significantly improve markers of prostate proliferation. In addition, the strong lipid antioxidant properties of lycopene make it particularly effective in maintaining healthy LDL oxidation and protecting against free radical activity on the arterial wall.
Inositol is a key intermediate of secondary messengers and a primary component of cellular membrane phospholipids which is involved in a number of biological processes. Inositol has been found to be essential for calcium and insulin signal transduction, and serotonin activity modulation. Recent research indicates inositol is beneficial for stabilizing moods.