A review published online on July 28, 2010 in the journal Experimental Biology and Medicine recommends the implementation of global policy changes in order to improve the amount of vitamin D that people receive. "Responsible medicine demands that worldwide vitamin D nutritional guidelines reflect current scientific knowledge about vitamin D’s spectrum of activities," write vitamin D expert Anthony Norman of the University of California, Riverside and Roger Bouillon of the Laboratory of Experimental Medicine and Endocrinology at the Katholieke Universiteit Leuven in Belgium.
Vitamin D plays a critical role in the calcium homeostasis system, which involves the skeleton, intestine, kidneys and parathyroid glands. Other systems in which the vitamin is involved are the immune system, the pancreas and metabolic homeostasis, the cardiovascular system, muscle and brain systems, and the cell cycle. The current U.S. recommended daily intake of vitamin D is 200 international units (IU) for individuals up to the age of 50, 400 IU for those 51 to 70, and 600 IU for men and women over the age of 70. "Worldwide public health is best served by a recommendation of higher daily intakes of vitamin D," Dr Norman stated. "Currently, more than half the world's population gets insufficient amounts of this vitamin. At present about half of elderly North Americans and Western Europeans and probably also of the rest of the world are not receiving enough vitamin D to maintain healthy bone."
The authors note that increased sun exposure to elevate vitamin D levels is not a viable option for most individuals due to the carcinogenicity of ultraviolet B. Additionally, there are no foods that contain enough naturally occurring amounts of the vitamin to correct the worldwide lack. While food fortification could help, the choice of which foods should be fortified and what dosage to fortify them with is challenging because food preferences vary, which could leave vulnerable groups deficient. Supplementation allows correct dosing dependent upon individual needs, but requires lifelong compliance.
Drs Norman and Bouillon suggest that an increase to 2,000 IU of vitamin D daily (or higher for some groups) could reduce the incidence of a number of diseases, including multiple sclerosis, cancer, type-1 diabetes, metabolic syndrome, cardiovascular disease and tuberculosis. "A reduction in the frequency of these diseases would increase the quality and longevity of life and significantly reduce the cost of medical care worldwide," Dr Norman observed. "It is high time that worldwide vitamin D nutritional policy, now at a crossroads, reflects current scientific knowledge about the vitamin's many benefits and develops a sound vision for the future."
It is common knowledge that calcium and vitamin D work together to help prevent osteoporosis. But what about the many other essential minerals and nutrients needed for bone health?
Vitamin D, a hormone-like substance, promotes the absorption of calcium. Vitamin D is made by the skin after exposure to sunlight or ultraviolet radiation, and vitamin D deficiency is widespread throughout the United States. People with light skin synthesize vitamin D in their skin easier than dark-skinned people. In the winter when people spend more time indoors and have less exposure to sunlight, their vitamin D levels plummet. Of special concern, vitamin D deficiency is a very important winter-time risk for people with dark-skin, who must have more exposure to sunlight than light-skinned people in order to generate similar amounts of vitamin D. Some people must avoid exposure to sunlight for various reasons, such as incompatibility of sunlight with certain medications.
Vitamin K facilitates the activity of calcium in bone building. Vitamin K is necessary for the activation of osteocalcin, a protein found in relatively high amounts in the bone, which allows calcium to bind to bone matrix. Osteocalcin that is not appropriately synthesized with vitamin K may lead to low bone mineral density and an increased risk of osteoporosis (Schaafsma A et al 2001; Okano T 2005).
Diets with more vegetables and less meat are higher in vitamin K. One study examined the relationship between vitamin K intake and hip fracture. Using 10 years of data on 72,000 participants in the Nurses’ Health Study, researchers found that study participants who received the most vitamin K were about a third less likely to get a hip fracture. Those who ate lettuce every day slashed their risk of hip fracture in half compared to those who ate it less than once a day (lettuce is a source of vitamin K) (Feskanich D et al 1999).
Vitamin K shows remarkable results against bone loss in postmenopausal women. A study of 1 mg vitamin K daily for two weeks demonstrated it increased the bone-building protein gamma-carboxyglutamic acid in women (Knapen MH et al 1989). Another study showed that vitamin K slowed calcium loss by one-third in people who have a tendency to lose it (Knapen MH et al 1993).
Scientists have known for years that certain biological components of whey protein (including lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, and immunoglobulins) have a beneficial impact on the immune system. Life Extension has developed a specially designed whey protein, using proprietary production methodology that has been shown to support healthy immune function, protect against free radical attack, and help maintain lean muscle mass.
Using a low temperature microfiltration technique, it is possible to produce a high-quality, 98% undenatured whey protein isolate that acts as a powerful immune stimulant and retains all the important sub-fractions, such as lactoferrin, a strong antioxidant with immune-stimulating properties. Life Extension offers whey protein powders in four flavors that contain added lactoferrin.
Zinc is a mineral that stimulates the activity of approximately 100 enzymes, which are substances that promote biochemical reactions in your body. These reactions are essential for the formation of superoxide dismutase, one of the body’s most important free radical scavengers. Zinc also promotes immune function, taste sensitivity, protein and DNA synthesis, insulin production, reproductive organ development and sperm motility. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence.
Age-related declines in immune function are associated with zinc deficiency, and the elderly represent a group that is vulnerable to mild zinc deficiency. Certain aspects of immune function in the elderly have been found to improve with zinc supplementation.