Tuesday, August 9, 2016
Study suggests supplementation with taurine and magnesium could decrease cardiovascular disease progression.
On July 14, 2016, the journal Hypertension Research reported the findings of an increase in endothelial progenitor cells and a decrease in free radical levels in association with supplementation with taurine and the mineral magnesium in rats and in humans. The body's endothelial progenitor cells repair damage to the lining of the arteries that leads to cardiovascular disease. Free radical formation, when unchecked, is another factor involved in cardiovascular disease development.
In the human study, 125 healthy men between the ages of 18 and 25 years received 3 grams taurine, 340 milligrams (mg) magnesium, or a placebo daily for two weeks. Taurine and magnesium supplementation decreased free radical levels and thiobarbituric acid reactive substance (TBARS) scores (a measure of lipid peroxidation) by the end of the treatment period. In comparison with pretreatment levels, endothelial progenitor cell colony-formation numbers, which reflect the vascular repair function of endothelial progenitor cells, significantly increased in taurine- and magnesium-supplemented participants.
The animal experiment included normal rats and spontaneously hypertensive rats that develop high blood pressure at five to six weeks of age. Both groups were provided with high-salt drinking water, which increases blood pressure. The spontaneously hypertensive rats were given taurine, magnesium, taurine plus magnesium, or a low magnesium diet for four weeks, while normal rats received a low magnesium diet.