Vitamins, Health Supplements, Anti Aging Supplements: Life Extension Update
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Tuesday, January 26, 2016
The results of a meta-analysis reported in the July 2015 issue of Biomedical and Environmental Sciences add more evidence in support of a relationship between higher magnesium intake and a lower risk of developing type 2 diabetes.
Researchers at China's Nantong University selected 15 articles that reported the results of 19 prospective studies examining the effect of dietary or dietary plus supplemental magnesium on type 2 diabetes incidence among a total of 539,735 men and women. Type 2 diabetes developed in 25,252 subjects over follow-up periods that ranged from four to twenty years.
According to authors Tian Xu and colleagues, the protective effect of magnesium on diabetes is believed to be mediated through glucose homeostasis. Magnesium deficiency is thought to damage beta-cells, thereby affecting insulin production. In addition, magnesium supplementation has been shown to prevent fructose-induced insulin insensitivity. They add that intervention trials have shown that magnesium supplementation improved insulin sensitivity, and reduced insulin resistance and plasma fasting glucose levels in diabetics and nondiabetics alike.
"The present meta-analysis of prospective cohort studies further verified a protective effect of magnesium intake on type 2 diabetes in a nonlinear dose-response manner," the authors conclude. "Increasing magnesium intake especially in those with low basic level would make a beneficial contribution to control type 2 diabetes risk in general population."