Life Extension Suggestions
Depression is a multifactorial condition, and efficient relief often requires addressing multiple neurochemical and metabolic imbalances that may underlie mood disturbances. The nutrients listed in this protocol are categorized according to their evidence-based mechanisms of action in brain health and mood regulation.
Many of these suggestions may serve as adjuvants to conventional therapies for depression. Always consult a qualified healthcare professional before combining any supplements with an antidepressant medication.
Broad-Range Nervous System Effects
- Fish oil (with olive polyphenols): 1400 mg EPA and 1000 mg DHA daily
- Magnesium L-Threonate: 2000 mg daily (supplying 144 mg elemental magnesium)
- Saffron extract: 176 mg daily
Supporting Neurotransmitter Synthesis
- Tryptophan: 1000 – 2000 mg daily
Supporting Methylation Reactions
- S-Adenosylmethionine (SAMe): 400 – 1200 mg daily
- L-methylfolate: 1000 mcg daily
- Vitamin B12 (as methylcobalamin): 1000 – 8000 mcg daily
- Vitamin B6 (as pyridoxal 5-phosphate): 100 mg daily
Supporting Blood Sugar Regulation
- Chromium: 500 mcg daily
- Green Coffee Bean extract (standardized 50% to chlorogenic acid): 400 mg before each meal, up to three times daily.
- N-Acetyl-cysteine: 600 – 1200 mg daily
- R-lipoic acid: 300 – 600 mg daily
- Vitamin C: 1000 – 2000 mg daily
- Vitamin E (as high gamma tocopherol mix): 350 mg daily
- Selenium (as Se-methylselenocysteine): 200 mcg daily
Supporting Mitochondrial Health
- Coenzyme Q10 (as ubiquinol): 100 – 200 mg daily
- Pyrroloquinoline quinine (PQQ): 10 – 20 mg daily
- Acetyl-L-Carnitine: 1000 – 2000 mg daily
Men and women with depression should consider restoring their hormone concentrations to youthful levels with the use of natural bioidentical hormones. More information is available in the Male Hormone Restoration and Female Hormone Restoration protocols. A natural, over-the-counter hormone men and women should consider optimizing is:
- DHEA: 15 – 50 mg daily for women or 25 – 75 mg daily for men
In addition, thyroid hormone irregularities may contribute to depression. Therefore, those with known or suspected thyroid dysfunction should refer to the Thyroid Regulation protocol.
Miscellaneous Mechanisms of Relief
- Vitamin D: 5000 – 8000 IU daily (depending on blood test results)
- Zinc: 30 mg daily
- Inositol: 2000 – 10 000 mg daily
- Comprehensive multivitamin / multinutrient formula: Per label instructions
- St. John's Wort; standardized extract: 300 – 600 mg daily
- Curcumin (as highly absorbed phospholipid blend): 630 mg daily
In addition, the following blood testing resources may be helpful:
- Female Panel / Male Panel
- Thyroid Panel (TSH, T4, Free T4, Free T3)
- Cortisol AM/PM
- Insulin (fasting)
- Vitamin B12 & Folate
- Vitamin D, 25-Hydroxy
- RBC Magnesium
- Omega Check™
- Cytokine Panel
Disclaimer and Safety Information
This information (and any accompanying material) is not intended to replace the attention or advice of a physician or other qualified health care professional. Anyone who wishes to embark on any dietary, drug, exercise, or other lifestyle change intended to prevent or treat a specific disease or condition should first consult with and seek clearance from a physician or other qualified health care professional. Pregnant women in particular should seek the advice of a physician before using any protocol listed on this website. The protocols described on this website are for adults only, unless otherwise specified. Product labels may contain important safety information and the most recent product information provided by the product manufacturers should be carefully reviewed prior to use to verify the dose, administration, and contraindications. National, state, and local laws may vary regarding the use and application of many of the treatments discussed. The reader assumes the risk of any injuries. The authors and publishers, their affiliates and assigns are not liable for any injury and/or damage to persons arising from this protocol and expressly disclaim responsibility for any adverse effects resulting from the use of the information contained herein.
The protocols raise many issues that are subject to change as new data emerge. None of our suggested protocol regimens can guarantee health benefits. The publisher has not performed independent verification of the data contained herein, and expressly disclaim responsibility for any error in literature.