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Ahmad MK, Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertil Steril. 2010;94(3):989-996.

Allen K et al. Pet ownership, but not ace inhibitor therapy, blunts home blood pressure responses to mental stress. Hypertension. 2001 Oct;38(4):815-20.

Amin KA, Awad EM, Nagy MA. Effects of panax quinquefolium on streptozotocin-induced diabetic rats: role of C-peptide, nitric oxide and oxidative stress. Int J Clin Exp Med. 2011;4(2):136-47.

Anacker C et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry. 2011 Jul;16(7):738-50. doi: 10.1038/mp.2011.26. Epub 2011 Apr 12.

Anderson DC. Assessment and nutraceutical management of stress-induced adrenal dysfunction. Integrative Medicine. 2008;7(5):18-25.

Anon., Calcium pantothenate in arthritic conditions. A report from the General Practitioner Research Group. Practitioner 1980;224:208-11.

Arseneault-Breard J, Rondeau I, Gilbert K, Girard SA, Tompkins TA, Godbout R, Rousseau G. Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model. The British journal of nutrition.Jun 2012;107(12):1793-1799.

Auddy B et al. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-controlled Study. 2008; 11(1):50-56.

Barker SB, Wolen AR. The benefits of human-companion animal interaction: a review. J Vet Med Educ. 2008 Winter;35(4):487-95.

Barrett-Connor, E., A Prospective Study of Dehydroepiandrosterone Sulfate, Mortality, and Cardiovascular Disease, N Engl J Med 1986; 315:1519-1524

Barton, DL., Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2010;18 (2): 179–187.

Beishuizen, A., Patterns of corticosteroid--binding globulin and the free cortisol index during sepsic shock and multitrauma. Intensive Care Med, 2001;27:1584-1591.

Benton D., The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-178.

Berg AL et al. The effects of adrenocorticotrophic hormone and cortisol on homocysteine and vitamin B concentrations. Clin Chem Lab Med. 2006;44(5):628-31.

Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytomedicine. 1998;5(2):77–82.

Bhattacharyya D, Sur TK, Jana U, et al. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008;10(3):176-179.

Binder EB et al. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010 Jun;15(6):574-88. Epub 2009 Dec 15.

Bornstein SR. Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocr Res. 2004 Nov;30(4):871-875.

Bradbury J., An adaptogenic role for omega-3 fatty acids in stress; a randomised placebo controlled double blind intervention study (pilot). Nutr J. 2004 11: 28.

Brandt. “The Adrenal Medulla”. Available at http://www.rose-hulman.edu/~brandt/Chem330/EndocrineNotes/Chapter_4_Adrenal_Medulla.pdf Accessed 1/6/2012

Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences of the United States of America. Sep 20 2011;108(38):16050-16055.

Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol. 1969a;9:419-30.

Brekhman II., Pharmacological investigation of glycosides from Ginseng and Eleutherococcus.Lloydia. 1969b;32:46-51.

Brody S., A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.Psychopharmacology (Berl). 2002;159:319-324.

Brown DW, Anda RF, Tiemeier H, et al. Adverse childhood experiences and the risk of premature mortality. Am J Prev Med. 2009 Nov;37(5):389-96.

Bruls E.,Melatonin. I. Physiology of its secretion]. Rev Med Liege. 2000 Aug;55(8):785-92.

Buoso E et al. Opposing effects of cortisol and dehydroepiandrosterone on the expression of the receptor for Activated C Kinase 1: implications in immunosenescence. Exp Gerontol. 2011 Nov;46(11):877-83. Epub 2011 Jul 27.

Calcaterra NE, Barrow JC. Classics in chemical neuroscience: diazepam (valium). ACS chemical neuroscience.Apr 16 2014;5(4):253-260.

Cao Y, Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running. J Ethnopharmacol. 2011 Aug 22.

Carroll D. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind, placebo-controlled trial. Psychopharmacology (Berl). 2000;150:220-225.

Cases J et al. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011 Dec;4(3):211-218. Epub 2010 Dec 17.

Chan TWD., Differentiation and Authentication of Panax ginseng, Panax quinquefolius, and Ginseng Products by Using HPCL/MS, Analytical Chemistry, 2000; 72 (10), 2329-2329.

Chen JK., Chinese Medical Herbology and Pharmacology, CA: Art of Medicine Press; 2004.

Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS. Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology. 2008 Jul;29(4):656-62.

Choudhary MI., Cholinesterase inhibiting withanolides from Withania somnifera. Chem Pharm Bull, 2004;52(11):1358-1361.

Chrousos G., The stress response and immune function: clinical implications., Ann N Y Acad Sci, 2000;917:38-67

Ciolino H., Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo. Int J Cancer 2003;105:321-325

Cooley K, Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974. PLoS ONE 2009; 4(8): e6628.

Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci.2012;13(10):701-712.

Daugherty M et al. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem. 2002 Jun 14;277(24):21431-9. Epub 2002 Mar 28.

Davydov M, Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology 2000; 72(3): 345–393.

De Bock K, Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004;14(3):298-307.

Delarue J., Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab. 2003 Jun;29(3):289-95.

Dhatariya K, Bigelow ML, et al. Effect of DHEA replacement on insulin sensitivity and lipids in hypoadrenal women.Diabetes . 2005 Mar;54(3):765-769.

Di X, Yan J, Zhao Y, et al. L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience. 2010 Jul 14;168(3):778-86.

Dimpfel W, Kler A, Kriesl E, Lehnfeld R, Keplinger-Dimpfel IK. Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin. Nutr Neurosci. 2007a Jun-Aug;10(3-4):169-80.

Dimpfel W, Kler A, Kriesl E, Lehnfeld R. Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: I. electrophysiological characterization in the rat hippocampus in-vitro. J Pharm Pharmacol. 2007b Aug;59(8):1131-6.

Dimpfel W., Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. Eur J Med Res. 2004 Sep 29;9(9):423-31.

Dinan TG, Cryan JF. Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology. Psychoneuroendocrinology.Sep 2012;37(9):1369-1378.

Dixit S., Executive fatigue and its management with Mentat. Pharmacopsychoecologia. 1993;6:7-9.

Eiland L et al. Early life stress followed by subsequent adult chronic stresspotentiates anxiety and blunts hippocampal structural remodeling. Hippocampus. 2010 Sep 16. doi: 10.1002/hipo.20862. [Epub ahead of print]

Eipper BA., The biosynthesis of neuropeptides: peptide alpha-amidation. Annu Rev Neurosci(1992). 15: 57–85.

Evans J, Antioxidant supplements to prevent or slow down the progression of AMD: a systematic review and meta-analysis, Eye.2008 Jun; 22(6):751-760.

Fahey TD., The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biol Sport. 1998;15:135-144.

Feldman HA, Johannes CB, et al. Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study. Ann Epidemiol . 1998 May;8(4):217-228.

Ferrari E, Cravello L, et al. Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates.Eur J Endocrinol . 2001 Apr;144(4):319-29.

Ferrari E., Cognitive and affective disorders in the elderly: a neuroendocrine study. Arch Gerontol Geriatr Suppl . 2004;(9):171-182.

Field, T., Cortisol decreases and serotonin and dopamine increase following massage therapy. The International journal of neuroscience 2005, 115 (10): 1397–1413.

Forsythe P, Kunze WA. Voices from within: gut microbes and the CNS. Cellular and molecular life sciences: CMLS.Jan 2013;70(1):55-69.

Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J. Mood and gut feelings. Brain Behav Immun.Jan 2010;24(1):9-16.

Foster JA, Lyte M, Meyer E, Cryan JF. Gut microbiota and brain function: An evolving field in neuroscience. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Oct 4 2015.

Friedmann E, Son H. The human-companion animal bond: how humans benefit. Vet Clin North Am Small Anim Pract. 2009 Mar;39(2):293-326.

Gaffney BT.,The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci.2001;70:431-442.

Gagnon A, Effects of Cu on plasma cortisol and cortisol secretion by adrenocortical cells of rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2006 10;78(1):59-65.

Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut.Nov 2007;56(11):1522-1528.

Gholap S and Kar A. Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Pharmazie. 2004;59(11):876-878.

Golf, Sw., On the significance of magnesium in extreme physical stress. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 1998, 12 2 (2suppl): 197–202.

Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009 Jun;22(1):44-51.

Gouin JP et al. Chronic stress, daily stressors, and circulating inflammatory markers. Health Psychol. 2011 Sep 19. [Epub ahead of print]

Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81(1):81-100.

Gupta P, Yadav DK, Siripurapu KB, et al. Constituents of Ocimum sanctum with antistress activity. J Nat Prod. 2007;70(9):1410-1416.

Hanley J,, Randomised controlled trial of therapeutic massage in the management of stress. Br J Gen Pract. 2003;53:20-25.

Head KA., Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140.

Heese T, Jenkinson J, Love C, et al. Anxiolytic effects of L-theanine--a component of green tea--when combined with midazolam, in the male Sprague-Dawley rat. AANA J. 2009 Dec;77(6):445-9.

Hellhammer, J., Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress (Amsterdam, Netherlands)2004, 7 (2): 119–126.

Hellman, L., Cholesterol synthesis from C14- Acetate in man, J Clin Invest. 1954 33(2): 142-149.

Hemila H. Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med 1996;17:379-833.

Heraclides A et al. Psychosocial stress at work doubles the risk of type 2 diabetes in middle-aged women: evidence from the Whitehall II study. Diabetes Care. 2009 Dec;32(12):2230-5.

Heraclides AM et al. Work Stress, Obesity and the Risk of Type 2 Diabetes: Gender-Specific Bidirectional Effect in the Whitehall II Study. Obesity (Silver Spring). 2011 May 19.

Hertoghe, T., speech recorded at the American Academy of Anti-Aging Medicine, Las Vegas, NV, 1999.

Hidalgo C., Effect of the lipid environment on protein motion and enzymatic activity of the sacroplasmic reticulum calcium ATPase, J Biol Chem 1978; 253:6879-6887.

Hirata F., Phospholipid methylation and biological signal transmission. Science, 1980;209:1082-1090.

Huang KC. The Pharmacology of Chinese Herbs, 2nd ed. New York: CRC Press; 1999.

Innes KE et al. Chronic stress and insulin resistance-related indices of cardiovascular disease risk, part I: neurophysiological responses and pathological sequelae. Altern Ther Health Med. 2007 Jul-Aug;13(4):46-52.

Jacobs JR et al. Early and chronic stress and their relation to breast cancer. Psychol Med. 2000 May;30(3):669-78.

James FO et al. Circadian rhythms of melatonin, cortisol, and clock gene expression during simulated night shift work. Sleep. 2007 Nov;30(11):1427-36.

Kakuda T. Neuroprotective effects of the green tea components theanine and catechins. Biol Pharm Bull. 2002 Dec;25(12):1513-8.

Kalaitzakis E., Is fatigue related to suppression of hypothalamic-pituitary-adrenal axis activity by bile acids in chronic liver disease?, Med Hypotheses. 2011.

Kameda W, Daimon M, et al. Association of decrease in serum DHEA-S levels with the progression to type 2 diabetes in men of a Japanese population: the Funagata study. Metabolism . 2005 May;54(5):669-676.

Karten YJ et al. Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13456-61.

Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev. 1999 Aug;4(4):249-65.

Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302.

Kennedy DO., Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20(2):96-102.

Kennedy DO., Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul;66(4):607-13.

Kiecolt-Glasser JK. Stress, food, and inflammation: psychoneuroimmunology andnutrition at the cutting edge. Psychosom Med. 2010 May;72(4):365-9. Epub 2010 Apr 21.

Kiho T, Ookubo K, Usui S, et al. Structural features and hypoglycemic activity of a polysaccharide (CS-F10) from the cultured mycelium of Cordyceps sinensis. Biol Pharm Bull. 1999;22(9):966-970.

Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45.

Kimura K., l-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2006;8: 21.

Kobayashi A. Trace element and hormonal responses during flight aptitude test. Aviat Space Environ Med. 1996;67(4):333-337.

Koh JH, Kim KM, Kim JM, et al. Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003;26(5):691-694.

Kondo N, Oh J. Suicide and karoshi (death from overwork) during the recent economic crisis in Japan: the impacts, mechanisms and political responses. J Epidemiol Community Health. 2010;64(8):649-50.

Korlakunta HL et al. Transient left ventricular apical ballooning: a novel heart syndrome. Int J Cardiol. 2005 Jul 10;102(2):351-3.

Krugers HJ et al. Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Front Synaptic Neurosci. 2010 Jul 12;2:24.

Kruk J. Self-reported psychological stress and the risk of breast cancer: A case-control study. Stress. 2011 Aug 29.

Kyrou I et al. Chronic stress, visceral obesity and gonadal dysfunction. Hormones (Athens). 2008 Oct-Dec;7(4):287-93.

Lasco A., Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women.Eur J Endocrinol . 2001 Oct;145(4):457-461.

Laszlo KD et al. Job strain predicts recurrent events after a first acute myocardial infarction: the Stockholm Heart Epidemiology Program. J Intern Med. 2010 Jun;267(6):599-611.

Lehrke M et al. Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions. Crit Care. 2008;12(6):R157. Epub 2008 Dec 17.

Leu SF, Chien CH, Tseng CY, et al. The in vivo effect of Cordyceps sinensis mycelium on plasma corticosterone level in male mouse. Biol Pharm Bull. 2005;28(9):1722-5.

Li SP, Zhao KJ, Ji ZN, et al. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sci. 2003;73(19):2503-2513.

Lipnick RL, Filov VA. Nikolai Vasilyevich Lazarev, toxicologist and pharmacologist, comes in from the cold. Trends Pharmacol Sci. 1992 Feb;13(2):56-60.

Liu L, Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress. Zhongguo Zhong Yao Za Zhi. 2011;36(10):1342-1347.

Liu RT et al. Stress generation in depression: A systematic review of the empirical literature and recommendations for future study. Clin Psychol Rev. 2010 Jul;30(5):582-93. Epub 2010 May 15.

Logan, A. Omega-3 fatty acids and major depression: A primer for the mental health professional. Lipids Health Dis. 2004; 3: 25.

Lovallo WR., Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacol. Biochem. Behav. 2006 83 (3): 441–447.

Ma SW, Benzie IF, Chu TT, et al. Effect of Panax ginseng supplementation on biomarkers of glucose tolerance, antioxidant status and oxidative stress in type 2 diabetic subjects: results of a placebo-controlled human intervention trial. Diabetes Obes Metab. 2008 Nov;10(11):1125-7. Epub 2008 Mar 18.

Maes M,. Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS. Neuro Endocrinol Lett. 2005;26(5): 487-492.

Majewska MD et al. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 1986 May 23;232(4753):1004-7.

Matthews KA et al. Chronic work stress and marital dissolution increase risk of posttrial mortality in men from the Multiple Risk Factor Intervention Trial. Arch Intern Med. 2002 Feb 11;162(3):309-15.

McEwen BS et al. Protective and damaging effects of stress mediators. N Engl J Med. 1998 Jan 15;338(3):171-9.

McEwen BS. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci. 2004 Dec;1032:1-7.

Mcmahon M, Gerich J, Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes/Metabolism Reviews. 1988;4(1):17-30.

Mechanic D. Effects of psychological distress on perceptions of physical health and use of medical and psychiatric facilities. J Human Stress 1978; 4:26-32.

Messaoudi M, Lalonde R, Violle N, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. The British journal of nutrition.Mar 2011;105(5):755-764.

Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes. Jul-Aug 2011;2(4):256-261.

Methlie P et al. Grapefruit juice and licorice increase cortisol availability in patients with Addison's disease. Eur J Endocrinol. 2011 Nov;165(5):761-9. Epub 2011 Sep 6.

Mishra LC, Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000 Aug;5(4):334-46.

Mitsushima D et al. Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects. Endocrinology. 2008 Feb;149(2):802-11. Epub 2007 Oct 25.

Mondal S, Varma S, Bamola VD, et al. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J Ethnopharmacol. 2011;136(3):452-456.

Monteleone, P., Effects of phosphatidylserine on the neuroendocrine responses to physical stress in humans., Neuroendocrinol. 1990, 52: 243-248.

Morfin R., (ed), DHEA and the Brain; Vol. 1, Taylor & Francis, NY, 2002.

Muneer, M. ADRENAL GLANDS published online similima.com, retrieved Aug 20, 2011.

Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S. Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem Biophys Res Commun. 2004 Jul 16;320(1):116-22.

Nagata A, Tajima T, Uchida M. Supplemental anti-fatigue effects of Cordyceps sinensis (tochu-kaso) extract powder during three stepwise exercise of human. Jpn J Phys Fitness Sports Med. 2005;55 Suppl.:S145-52.

Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.

Ng TB., Toxic effect of heavy metals on cells isolated from the rat adrenal and testis. In Vitro Cell Dev Biol. 1990;26(1):24-8.

Nielsen NR et al. Perceived stress and cause-specific mortality among men and women: results from a prospective cohort study. Am J Epidemiol. 2008 Sep 1;168(5):481-91; discussion 92-6.

Nilsson PM et al. Sleep disturbance in association with elevated pulse rate for prediction of mortality--consequences of mental strain? J Intern Med. 2001 Dec;250(6):521-9.

Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.

Olsson EM et al. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12.

Panossian A, Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219.

Panossian A. Adaptogens. Tonic herbs for fatiuge and stress. Altern Complement Ther. 2003;9(6):327-331.

Panossian A., Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration., Phytother Res. 2005;19(10):819-838.

Patacchioli FR et al. Menopause, mild psychological stress and salivary cortisol: influence of long-term hormone replacement therapy (HRT). Maturitas. 2006 Sep 20;55(2):150-5. Epub 2006 Mar 6.

Pawlikowski M., Effects of six months melatonin treatment on sleep quality and serum concentrations of estradiol, cortisol, dehydroepiandrosterone sulfate, and somatomedin C in elderly women. Neuroendocrinol Lett. 2002;23 Suppl 1:17-19.

Peters EM, Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. Int J Sports Med. 2001 (7):537-543.

Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC. Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. Clinical therapeutics.May 1 2015;37(5):984-995.

Ping J et al. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells. Chem Biol Interact. 2012 Jan 5;195(1):68-75. Epub 2011 Nov 12.

Plesofsky-Vig N., Pantothenic acid. In: Shils ME, eds. Modern Nutrition in Health and Disease, 8th ed. Malvern, PA: Lea & Febiger, 1994.

Pluess TT et al. Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects. Intensive Care Med. 2007 May;33(5):789-97. Epub 2007 Mar 22.

Pozza C, Graziadio C, Giannetta E, et al. Management Strategies for Aggressive Cushing's Syndrome: From Macroadenomas to Ectopics. J Oncol. 2012;685213.

Presman DM et al. Melatonin inhibits glucocorticoid-dependent GR-TIF2 interaction in newborn hamster kidney (BHK) cells. Mol Cell Endocrinol. 2012 Feb 26;349(2):214-21. Epub 2011 Nov 4.

Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007;60(2):122-124.

Rasmuson S, Näsman B, Calström K, et el. Increased levels of adrenocortical and gonadal hormones in mild to moderate Alzheimer’s disease. Dement Geriatr Cogn Disord. 2002;13(2):74-9.

Reiter RJ,. Melatonin: an antioxidant in edible plants. Ann N Y Acad Sci. 2002 May;957:341-4.

Rocha Araujo DM., What is the effectiveness of the use of polyunsaturated fatty acid omega-3 in the treatment of depression? Expert Rev Neurother. 2010; 10(7):1117-1129.

Roepke SK et al. Relationship between chronic stress and carotid intima-media thickness (IMT) in elderly Alzheimer's disease caregivers. Stress. 2011 Jul 26. [Epub ahead of print]

Sakihara S et al. Ampulla (Takotsubo) cardiomyopathy caused by secondary adrenal insufficiency in ACTH isolated deficiency. Endocr J. 2007 Aug;54(4):631-6. Epub 2007 Jul 31.

Salavecz G et al. Work stress and health in Western European and post-communist countries: an East-West comparison study. J Epidemiol Community Health. 2010 Jan;64(1):57-62.

Saleeby, Y., Wonder Herbs: A guide to three adaptogens, Xlibris 2006.

Sanders ME. Probiotics: Definition, Sources, Selection, and Uses. Clinical Infectious Diseases.February 1, 2008 2008;46(Supplement 2):S58-S61.

Sapolsky, RM, Endocrinology of the stress-response, Behavioral Endocrinology, 2nd ed. MIT, Press, Cambridge, MA, 2002 pp. 409–450.

Saul AN et al. Chronic stress and susceptibility to skin cancer. J Natl Cancer Inst. 2005 Dec 7;97(23):1760-7.

Schambelan M., Licorice ingestion and blood pressure regulating hormones., Steroids.1994;59(2):127-130.

Schmidt PJ., DHEA monotherapy in midlife-onset and minor depression. Arch Gen Psychiatry. 2005 Feb;62(2):154-162.

Schulz V., Rational Phytotherapy: A Physicians' Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 1998:271, 273.

Sen S, American ginseng (Panax quinquefolius) prevents glucose-induced oxidative stress and associated endothelial abnormalities. Phytomedicine. 2011;18(13):1110-7.

Servan-Schreiber D., Somatizing Patients: Part I. Practical Diagnosis., AAFP, 2000, 2:1073-1080.

Sheikh N, Ahmad A, Siripurapu KB, et al. Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. J Ethnopharmacol. 2007;111(3):671-676.

Shevtsov VA, A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105.

Shufelt, C., DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health--National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE). J Clin Endocrinol Metab. 2010 Nov;95(11):4985-4992.

Siddiqui, I., Serum Copper levels in various diseases: A local experience at Aga Khan University Hospital, Karachi, AKUH 2001 Abstract.

Siegel GJ et al. “Basic Neurochemistry; moolecular, cellular, and medical aspects”, 7th Edition. Elsvier Academic Press 2006. Pg 895.

Silvers KM., Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids. 2005;72:211-218.

Sinha R et al. Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: implications for relapse susceptibility. Exp Clin Psychopharmacol. 2007 Oct;15(5):445-52.

Soszynski P., Decreased melatonin concentration in Cushing's syndrome., Horm Metab Res. 1989;21(12):673-674.

Spasov AA., A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-89.

Stancheva SL, Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med Physiol 1987;40:85-87.

Stough CK, Pase MP, Cropley V, et al. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr J. 2012;11:11.

Strohle A et al. Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry. 2003 Nov;36 Suppl 3:S207-14.

Strous RD, Maayan R, Lapidus R, et al. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 2003;60:133-141.

Sun LJ, Wang GH, Wu B, et al. [Effects of schisandra on the function of the pituitary-adrenal cortex, gonadal axis and carbohydrate metabolism in rats undergoing experimental chronic psychological stress, navigation and strenuous exercise]. Zhonghua Nan Ke Xue. 2009;15(2):126-129.

Tahiliani AG, Beinlich CJ. Pantothenic acid in health and disease. Vitam Horm. 1991;46:165-228.

Tak LM. Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biol Phychol. 2011;87(2):183-194.

Tak LM., Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biol Psychol. 2011;87(2):183-194.

Tarasov IuA, Sheĭbak VM, Moĭseenok AG. [Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives]. Vopr Pitan. 1985;(4):51-4. [Article in Russian]

Tarasov IuA, Sheĭbak VM, Moĭseenok AG. [Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives]. Vopr Pitan. 1985;(4):51-4. [Article in Russian]

Thaker PH et al. The neuroendocrine impact of chronic stress on cancer. Cell Cycle. 2007 Feb 15;6(4):430-3. Epub 2007 Feb 9.

Tohda C, Search for natural products related to regeneration of the neuronal network. Neurosignals. 2005;14(1-2):34-45.

Tomlinson, J., 11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid., Response Endocrine Reviews, 2004, 25: 831-866.

van Broekhoven F., Neurosteroids in depression: a review. Psychopharmacology (Berl) . 2003 Jan;165(2):97-110.

van Diermen D, Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009;122(2):397-401.

van Riel E et al. Chronic unpredictable stress causes attenuation of serotonin responses in cornu ammonis 1 pyramidal neurons. Neuroscience. 2003;120(3):649-58.

Veltman JC et al. Regulatory effect of copper on rat adrenal cytochrome P-450 and steroid metabolism. Biochem Pharmacol. 1986 Sep 1;35(17):2903-9.

Villareal DT. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA . 2004 Nov 10;292(18):2243-8.

Villareal DT., Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf) 2000;53:561-568.

Viner, R., Putting stress in Life: Hans Selye and the making of stress theory., Social Studies of Science, 1999, Vol. 29, No. 3, 391-410.

Vuong QV, Bowyer MC, Roach PD. L-theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011a Aug 30;91(11):1931-9.

Vuong QV, Stathopoulos CE, Golding JB, Nguyen MH, Roach PD. Optimum conditions for the water extraction of L-theanine from green tea. J Sep Sci. 2011b Jul 7.

Wakabayashi C, Numakawa T, Ninomiya M, Chiba S, Kunugi H. Behavioral and molecular evidence for psychotropic effects in L: -theanine. Psychopharmacology (Berl). 2011 Aug 23.

Wang J, Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng. J Ethnopharmacol. 2010; 20;130(2):421-423.

Warren G,. The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand. 1999;99(2):112-116.

Webster MJ., Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives. Eur J Appl Physiol Occup Physiol 1998;77:486-91.

Weerth, C., Development of cortisol circadian rhythm in infancy , Early Human Development, 2003, Vol. 73, Issue 1, Pages 39-52.

Wilborn, D., Effects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and Catabolism., Journal of the International Society of Sports Nutrition 2004;1 (2): 12–20.

Willis AL., Nutritional and pharmacologic factors in eicosanoid biology. Nutr Rev 1981; 39:289-301.

Wirth, M., Shiftwork duration and the awakening cortisol response among police officers., Chronobiol Int. 2011 ;28(5):446-57.

Wolkowitz OM, Reus VI, Keebler A, et al. Double-blind treatment of major depression with dehydroepiandosterone. Am J Psychiatry 1999;156:646-649.

Wolkowitz OM, Reus VI, Manfredi F, et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry 1997;41:311-318.

Wu, JY., Adrenal insufficiency in prolonged critical illness, Cirt Care. 2008, 12(3): R65.

Yasuda K, Hiraoka M. [Pantothenic acid]. Nihon Rinsho. 2004;62 Suppl 12:198-202. [Article in Japanese]

Yin C, Gou L, Liu Y, et al. Antidepressant-like Effects of L-theanine in the Forced Swim and Tail Suspension Tests in Mice. Phytother Res. 2011 Mar 21.

Zaluska M et al. [Dehydroepiandrosteron (DHEA) in the mechanisms of stress and depression]. Psychiatr Pol. 2009 May-Jun;43(3):263-74.