Your Trusted Brand for Over 35 Years

This item is not available for purchase over the web or is obsolete.


  • Gentle-C™
  • 1000 mg 100 tablets
  • Item Catalog Number: 16787

Vitamin C, or ascorbic acid, is a white, crystalline, water-soluble substance found in citrus fruits. As an antioxidant, vitamin C scavenges free radicals in the body and protects tissues from oxidative stress.1-8 Vitamin C also promotes the absorption of iron, while preventing its oxidation.9,10 Vitamin C is a vital cofactor to the formation of collagen, the connective tissue that supports arterial walls, skin, bones, and teeth.4-6 A major immune-supporting activity of vitamin C is boosting glutathione levels in human lymphocytes,38 cells that make up about 25% of all white cells in the blood.

More vitamin C is contained in the adrenal glands than any other organ in the body and is required at higher levels during times of stress.11-14 Physical stresses on the body such as ingestion of heavy metals,15-20 cigarette smoking,21-24 immune impairment,25-31 extreme temperatures,31-36 and chronic use of certain medications such as aspirin also signal the need for increased intake of vitamin C.37

This TwinLab® product contains a unique calcium-bound ascorbate complex. This is a non-acidic form of vitamin C that may have a longer serum half-life than regular ascorbic acid. The product also contains a citrus bioflavonoid complex.

1. Biochim Biophys Acta. 2012 Dec;1826(2):443-57.
2. Redox Rep. 2010;15(1):11-9.
3. Adv Nutr. 2011 Mar;2(2):78-88.
4. Altern Med Rev. 2003 Nov;8(4):359-77.
5. J Invest Dermatol. 2002 Apr;118(4):565-72.
6. Radiat Environ Biophys. 2007 Mar;46(1):61-8.
7. Free Radic Biol Med. 2007 Sep 1;43(5):853-9.
8. PLoS Negl Trop Dis. 2012;6(7):e1729.
9. Br J Nutr. 2003 Dec;90(6):1081-5.
10. Am J Clin Nutr. 2006 Oct;84(4):830-4.
11. In Vivo. 1994 Nov-Dec;8(6):1079-85.
12. Ann Nutr Metab. 1990;34(2):85-92.
13. Psychopharmacology (Berl). 2002 Jan;159(3):319-24
14. Am J Clin Nutr. 2007 Jul;86(1):145-9.
15. Genet Test Mol Biomarkers. 2012 Sep;16(9):1001-6.
16. Environ Toxicol Pharmacol. 2011 Jan;31(1):137-42.
17. Acta Biochim Biophys Sin (Shanghai). 2012 Apr;44(4):330-8.
18.Nig Q J Hosp Med. 2012 Apr-Jun;22(2):85-90.
19. Toxicology. 2005 Jul 1;211(1-2):26-35. 
20. Chem Biol Interact. 2001 Jul 31;137(1):75-88.
21. Environ Health Perspect. 2000 Feb;108(2):105-8.
22. Am J Ther. 2007 Mar-Apr;14(2):189-93.
23. Am J Clin Nutr. 2000 Feb;71(2):530-6.
24. Toxicology. 2002 Nov 15;180(2):121-37.
25. J Am Coll Cardiol. 2003 Nov 5;42(9):1656-62.
26. J Pediatr Gastroenterol Nutr. 2003 Jul;37(1):53-62.
27. Cancer Sci. 2003 Apr;94(4):378-82.
28. Adv Ther. 2002 May-Jun;19(3):151-9.
29. Br J Dermatol. 1980 Jan;102(1):49-56.
30. Respir Med. 2007 Aug;101(8):1770-8.
31. Acta Obstet Gynecol Scand. 2007;86(7):783-7.
32. J Int Med Res. 2012;40(1):28-42.
33. Vopr Pitan. 1978 Jan-Feb;(1):44-8.
34. J Am Coll Nutr. 1990 Apr;9(2):150-4.
35. Jpn J Physiol. 1999 Apr;49(2):159-67.
36. Indian J Med Res. 2002 Jul;116:29-34.
37. Med Sci Monit. 2001 Jul-Aug;7(4):592-9.


Supplement Facts

Serving Size 1 tablet

Servings Per Container 100

Amount Per Serving

Ester-C calcium ascorbate

1100 mg



Vitamin C

1000 mg

Elemental calcium

100 mg

Citrus bioflavonoid complex

200 mg

Other ingredients: cellulose, croscarmelose sodium, vegetable based stearic acid, dicalcium phosphate, triacetin, magnesium silicate, caruba powder, purified water.
100% vegetarian tablets. Free of sugars, salt (sodium), wheat, starch, yeast, dairy, artificial colors, flavors and preservatives.

Dosage and Use
  • One or more tablets daily with a meal is suggested, or as directed by a healthcare practitioner.


Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer.