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In 1981, the Life Extension Foundation® introduced DHEA (dehydroepiandrosterone) to its members through an article that described the multiple benefits this hormone might produce. However, the general public did not learn about DHEA until 1996, when its benefits were touted by the news media and in several popular books. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book provided scientific validation for the many life-extending effects of DHEA.
Since 1981, several hundred studies have been published on DHEA’s various benefits, including immunomodulatory properties as well as positive effects on mood, quality of life, and body composition. It has been proposed that restoring the circulating levels of DHEA to those found in young people may improve well-being and sexual function. In a recent randomized, double-blind, placebo-controlled study, ten months of DHEA replacement therapy has the beneficial effect of enhancing the increases in muscle mass and strength with the addition of resistance exercise in elderly individuals.4 The studies of DHEA therapy in women with adrenal insufficiency also suggest beneficial effects on well-being, mood, and sexuality.5 DHEA could be of benefit to the normal aging brain.6-8 Some studies have reported DHEA may improve mood and alleviate melancholy.9 In addition, recent studies in vitro have shown that DHEA has the capacity to improve endothelial function by increasing nitric oxide (NO) synthesis.10
DHEA usage and safety precautions
Life Extension® has been investigating DHEA for almost 30 years. Life Extension’s directions for DHEA use are specially drafted to provide optimal, but safe dosing.
The standard blood test to evaluate DHEA status is one that measures DHEA sulfate levels (DHEA-S). The DHEA-S is calculated in micrograms per deciliter (μ/dL) of blood. A DHEA-S (dehydroepiandrosterone sulfate) blood test may be taken three to six weeks after initiating a DHEA supplementation regimen to help determine optimal dosing. When having your blood tested for DHEA, blood should be drawn three to four hours after the last dose. DHEA testing may save you money if it shows you can take less DHEA to maintain youthful DHEA serum levels.
Because of the overwhelming evidence connecting low levels of DHEA to problems associated with aging, Life Extension suggests that all people over age 40 begin DHEA therapy. For most people, the starting dose of DHEA is between 15–75 mg, taken in one daily dose. Many studies have used a daily dose of 50 mg.
Ideally, DHEA replacement therapy should begin with blood testing to establish a base range. Since almost everyone over age 35–40 has lower than optimal levels of DHEA, most people begin supplementation and test their blood DHEA levels later to make sure they are taking the proper dose. Normal serum reference ranges and ideal ranges of DHEA-S are:
People over age 40 who do not supplement with DHEA usually have serum levels below 200, and many are below 100 as a steady decline takes place after the third decade in life.1,12,14 There are different precautions for men and women that should be observed.
DHEA precautions for men
Before attempting to restore DHEA to youthful levels, men should know their serum PSA (prostate specific antigen) level. Men with prostate cancer or severe benign prostate disease are advised to avoid DHEA since it can be converted into testosterone (and estrogen). Therefore, men are advised to have a PSA and digital rectal exam before initiating DHEA to rule out existing prostate disease.
It is important for men over 40 to have a physician check their PSA and DHEA-S serum levels every six to twelve months thereafter. Men should also periodically check their blood levels for free testosterone and estrogen to make sure that DHEA is following a youthful metabolic pathway.
DHEA precautions for women
Women should consider estrogen and testosterone testing when they take their DHEA blood test in order to evaluate DHEA’s effect on their blood levels of these hormones. Women who have been diagnosed with an estrogen-dependent cancer should consult their physicians before beginning the DHEA restoration process.
1. J Clin Endocrinol Metab. 1992 Oct;75(4):1002-4.
2. J Clin Endocrinol Metab. 1997 Aug;82(8):2396-402.
3. Clin Chim Acta. 2004 Mar;341(1-2):1-15.
4. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1003-8.
5. Hum Reprod Update. 2007 May-Jun;13(3):239-48.)
6. J Endocrinol Invest. 2002 Jan;25(1):73-83.
7. Biogerontology. 2008 Aug;9(4):235-46.
8. Ann N Y Acad Sci. 2006 Nov;1088:139-52.
9. Psychopharmacology (Berl). 2006 Nov;188(4):541-51.
10. J Endocrinol Invest. 2005;28(3 Suppl):85-93.
11. J Clin Endocrinol Metab. 2006 Aug;91(8):2986-93
12. J Med Assoc Thai. 2001 Oct;84 Suppl 2:S605-12.
13. Clin Endocrinol (Oxf). 2006 Mar;64(3):260-4
14. J Endocrinol. 1999 Oct;163(1):1-5.
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