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Throughout life, cells known as osteoblasts construct bone matrix and fill it with calcium. At the same time, osteoclasts work just as busily to tear down and resorb bone. This fine balance is regulated by many factors, including systemic hormones and cytokines. Bone mass reaches its peak by the middle of the third decade of life and plateaus for about ten years, during which time bone turnover is constant, with bone formation approximately equaling bone resorption.1,2
As our bodies age, this fine balance is lost. As the relative hormone levels shift in midlife — more drastically in women than in men — the osteoclasts gain the upper hand and bone mass begins to dwindle. Some bone is already being lost by the time women reach menopause, but the rate of loss can increase up to tenfold during the first five years after menopause.2-4
Bone density loss is not just associated with calcium deficiency, but also with an insufficient intake of a host of other nutrients5-12 including magnesium11,12 and vitamin D3.13,14 In order for calcium to help maintain healthy bones, adequate amounts of vitamin D3, zinc,15,16 magnesium,17 manganese,9 and other nutrients should be available so that calcium and phosphorus can be incorporated into the bone matrix. Additionally, many forms of calcium are not particularly well absorbed.18-20
While loss of bone mineral density is more commonly experienced by women, aging men can also have this issue.21 Both men and women may experience significant deficits of magnesium if they do not supplement. Bone Restore now contains 300 mg of magnesium. Magnesium is not only needed to maintain strong bones, but it is critical to promoting a healthy vascular system.22,23 In fact, magnesium is critical for facilitating hundreds of enzymatic reactions that our bodies require to maintain optimal health.24,25
To overcome the impediments that preclude aging adults from achieving optimal calcium status, Life Extension offers a proprietary comprehensive mineral formula called Bone Restore which has been designed to support healthy bone density and strength. Bone Restore provides 700 milligrams of elemental calcium from three different forms, along with the critically important nutrients magnesium,17 boron,5,26,27 zinc,8,15,16 silicon,28-30 manganese9 and vitamin D313,14 needed for healthy bones.
In fact, the boron in this formula, called FruiteX B® OsteoBoron®, is a calcium/carbohydrate/boron complex, similar to what is found in fruits and vegetables and is more bioavailable than boron citrate. Scientific research has established the beneficial effects of boron on the strength of bones and joints.5,31-34
One reason why aging people experience bone mineral density loss even though they are taking calcium supplements is that they may not be absorbing enough elemental calcium. Bone Restore provides calcium in capsule form to ensure that it breaks down fully in the digestive tract.
Calcium and other minerals are best not taken with fiber, because fiber can interfere with their absorption.35-37 There is evidence that calcium from supplements and dairy foods may inhibit iron absorption, although it has been very difficult to distinguish between the effects of calcium on iron absorption versus other inhibitory factors, such as phytate.38-40 Although current understanding of this suggests that the inhibition of calcium on absorption of iron is of short duration and the body has adaptive mechanisms.41
Calcium supplements are best taken with meals. They should always be taken with a full glass of water, juice, or other liquid to enhance solubility.42 If calcium-containing formulas are taken only once daily, they may be best taken in the evening.43
An abundance of human clinical data reveals that vitamin K plays a critical role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone.44-48 Poor vitamin K status also results in increased circulating levels of undercarboxylated osteocalcin that is shown to be associated with increased bone loss in postmenopausal women.49,50
Vitamin K2 (menaquinones) is found in meat, eggs, and dairy products and is also made by bacteria in the human gut, which provides a certain amount of the human vitamin K requirement.51 Human studies show that vitamin K2 is up to ten times more bioavailable than K1. Vitamin K2 remains biologically active in the body far longer than K1.
In recent years, two forms of vitamin K2 have been extensively researched and the findings reveal vastly improved effects compared to K1. The MK-7 form of K2 remains bioavailable to the human body over a sustained 24-hour period and to higher levels (seven- to eightfold) during prolonged intake.48
So it’s not surprising that Bone Restore is now available with vitamin K2 (MK-7) for those not getting their vitamin K from Super Booster or Super K.
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2. Rheum Dis Clin N Am 33 (2007) 149-176
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10. Crit Rev Food Sci Nutr. 2006;46(8):621-8.
11. Magnes Res. 1993 Jun;6(2):155-63.
12. J Reprod Med. 1990 May;35(5):503-7.
13. J Clin Endocrinol Metab. 2010 Jun;95(6):2630-3.
14. Am J Clin Nutr. 1995 Mar;61(3 Suppl):638S-45S.
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20. Scand J Gastroenterol. 2010;45(2):133-8.
21. Osteoporos Int. 2009 Jul;20(7):1175-82.
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24. Front Biosci. 2004 May 1;9:1278-93.
25. South Med J. 2001 Dec;94(12):1195-201.
26. PDR for Nutritional Supplements, 1st ed. Montvale, NJ: Medical Economics Co.; 2001:60-3.
27. Environ Health Perspect. 1994 Nov;102 Suppl 7:59-63.
28. Bone. 2003 Feb;32(2):127-35.
29. Magnes Res. 1993 Sep;6(3):247-9.
30. Biol Trace Elem Res. 2009 Jun;128(3):239-47.
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33. Prog Food Nutr Sci. 1993 Oct-Dec;17(4):331-49.
34. Nutr Rev. 2008 Apr;66(4):183-91.
35. Am J Clin Nutr. 2010 May;91(5):1461S-1467S.
36. Diabetes Care. 2009 Jun;32(6):990-5.
37. Am J Clin Nutr. 2010 May;91(5):1430S-1432S.
38. Institute of Medicine Washington, DC: National Academy Press, 2001. http://www.nap.edu/openbook.php?record_id=10026&page=292
39. Am J Clin Nutr. 1991 Jan;53(1):106-11.
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43. J Clin Endocrinol Metab. 1994 Sep;79(3):730-5.
44. J Bone Miner Metab. 2001;19(3):146-9.
45. Osteoporos Int. 2007 Jul;18(7):963-72.,
46. J Bone Miner Res. 2007 Apr;22(4):509-19.
47. Natural Vitamin K2 as Menaquinone-7. Monograph April 2006
48. Blood. 2007 Apr 15;109(8):3279-83.
49. Vitam Horm. 2008;78:393-416.
50. Curr Drug Saf. 2006 Jan;1(1):87-97.
51. Prog Food Nutr Sci. 1992 Oct-Dec;16(4):307-43
Fruitex B® and OsteoBoron® are registered trademarks of VDF Futureceuticals, Inc. U.S. patent #5,962,049.
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