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Meta-analysis concludes protective effect for calcium supplementation against adenoma risk

May 23 2016. The May 14, 2016 issue of the World Journal of Gastroenterology published the results of a systematic review and meta-analysis of randomized trials that indicate a protective effect for calcium supplementation against the risk of colorectal adenoma, a precursor of colorectal cancer.

European researchers selected four trials that compared the effects of 1,200 to 2,000 milligrams elemental calcium per day to a placebo against the risk of colorectal adenoma during up to 60 months of treatment and follow-up. Subjects included men and women with resected colorectal cancer or those who had colorectal adenomas surgically removed prior to enrollment. Colonoscopic examinations conducted over the follow-up periods ascertained colorectal adenoma recurrence.  

All of the trials reported a lower incidence of colorectal adenomas in the calcium group. The meta-analysis determined that subjects who received calcium experienced a 10% to 15% lower risk of adenoma recurrence compared with those who received the placebos.

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