What's Hot in Nutrition, Dietary Supplements, Health and Wellness Today
What's Hot features original summaries of the latest peer-reviewed journal articles published in the fields of longevity, dietary supplements, health and wellness, and nutrition. Access the latest news concerning nutritional supplements and vitamins online at What's Hot each Monday, Wednesday and Friday. Articles are archived by month and year of publication for easy retrieval. What's Hot reports exciting findings on everything from the vitamins and supplements you and your family use on a daily basis to advanced high tech breakthroughs in the field of gerontology.
We invite you to browse the What's Hot archive to view past headlines in the areas of nutrition, health and wellness that the majority of the public are still unaware of.
Mayo researchers identify fisetin as a senolytic
March 22 2017. An article that appeared on March 8, 2017 in the journal Aging reports the identification of three more compounds that may delay some of the effects aging by targeting aged cells for destruction. The agents include the BCL-XL inhibitors A1331852 and A1155463 (which inhibit an antiapoptotic protein), and fisetin, which occurs in plants and is available in some supplements.
“Senescent cells accumulate with age and at sites of multiple chronic conditions, such as in fat tissue in diabetes, the lungs in chronic pulmonary diseases, the aorta in vascular disease, or the joints in osteoarthritis,” explained senior author James Kirkland, MD, PhD, who is the director of the Robert and Arlene Kogod Center on Aging. “At Mayo Clinic, we discovered the first senolytic drugs – agents that selectively eliminate senescent cells while leaving normal cells unaffected. These senolytic agents alleviated a range of age- and disease-related problems in mice. We used the hypothesis-driven approach that we used to discover the first senolytic drugs, two published in early 2015 and another later in 2015, to discover these three new senolytic drugs.”
Vitamins and supplements news are posted here frequently to keep you up-to-date with the latest advances in health and wellness. We have an unparalleled track record of breaking stories about dietary supplements and life extension advances.