New Science Study Results from University Hospital Described (Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1 beta activities before and after oral consumption)
By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Science. According to news reporting out of Nantes, France, by NewsRx editors, research stated, "Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects."
Our news journalists obtained a quote from the research from University Hospital, "To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and chondroprotective actions, (ii) exert anti-osteoarthritis effects in two post-traumatic animal models and (iii) retain its bioactivity after oral administration. Anti-inflammatory and chondroprotective actions of HT/PCy were tested on primary cultured rabbit chondrocytes stimulated by interleukin-1 beta (IL-1 beta). The results showed that HT/PCy exerts anti-inflammatory and chondroprotective actions in vitro. The preventive effect of HT/PCy association was assessed in two animal models of post-traumatic OA in mice and rabbits. Diet supplementation with HT/PCy significantly decreased the severity of post-traumatic osteoarthritis in two complementary mice and rabbit models. The bioavailability and bioactivity was evaluated following gavage with HT/PCy in rabbits. Regular metabolites from HT/PCy extract were found in sera from rabbits following oral intake. Finally, sera from rabbits force-fed with HT/PCy conserved anti-IL-1 beta effect, suggesting the bioactivity of this extract."
According to the news editors, the research concluded: "To conclude, HT/PCy extract may be of clinical significance for the preventive treatment of osteoarthritis."
For more information on this research see: Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1 beta activities before and after oral consumption. Scientific Reports, 2016;6():1-14. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)
Our news journalists report that additional information may be obtained by contacting Nantes, PHU OTONN 4, F-44042 Nantes, France. Additional authors for this research include C. Merceron, C. Vinatier, S. Krisa, T. Richard, M. Masson, J. Lesoeur, V. Hivernaud, O. Gauthier, J. Abadie, G. Nourissat, X. Houard, Y. Wittrant, N. Urban, L. Beck and J. Guicheux (see also Science).
Keywords for this news article include: Nantes, France, Europe, Science, University Hospital.
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